Epidermal Nevus
Jessica M. Comstock, MD
Key Facts
Terminology
Developmental malformation of epidermis with keratinocytic hyperplasia
Etiology/Pathogenesis
Epidermal nevus syndrome includes neurological, ocular, and skeletal abnormalities
Clinical Issues
Common sites include neck, trunk, and extremities
Microscopic Pathology
At least 10 different patterns
> 1 pattern can exist in single lesion
Common pattern includes hyperkeratosis with papillomatosis and acanthosis
ILVEN is considered a subtype of epidermal nevus
Top Differential Diagnoses
Seborrheic keratosis
Acanthosis nigricans
 Epidermal nevus is shown presenting as a warty, broad band of hypopigmented growth over the dorsal forearm and extensor wrist, extending onto the back of this child’s hand. (Courtesy Univ. of Utah Dept. of Dermatology.) |
 Low magnification shows a common type of epidermal nevus with prominent hyperkeratosis  , papillomatosis  , and acanthosis  . |
TERMINOLOGY
Synonyms
Nevus verrucosus
Localized wart-like variants
Nevus unius lateris
Long linear lesions on extremities
Ichthyosis hystrix
Large bilateral lesions on trunk
Definitions
Developmental malformation of epidermis with hyperplasia of keratinocytes
Specific entity that does not include adnexal malformations or appendageal tumors such as organoid/sebaceous nevus
ETIOLOGY/PATHOGENESIS
Epidermal Nevus Syndrome
Epidermal nevi (usually extensive) with
Neurological abnormalities (epilepsy, mental retardation)
Stay updated, free articles. Join our Telegram channel
Full access? Get Clinical Tree
