Class
- Cholinesterase inhibitor, peripheral
Edrophonium
Commonly Prescribed for
(FDA approved in bold)
- Myasthenia gravis (MG) – diagnostic test
- Curare antagonist (to reverse respiratory depression)
Edrophonium
How the Drug Works
- Improves symptoms of MG by preventing the metabolism of acetylcholine by cholinesterase. This improves neuromuscular transmission in MG
Edrophonium
How Long Until It Works
- Less than 1 minute
Edrophonium
If It Works
- Usually assists with the differential diagnosis of MG. Pyridostigmine is used for long-term treatment
Edrophonium
If It Doesn’t Work
- If no effect with the 10 mg dose, question the diagnosis of MG
Edrophonium
Tests
- None
Adverse Effects (AEs)
Edrophonium
How Drug Causes AEs
- Pro-cholinergic properties of the drug
Edrophonium
Notable AEs
- Diarrhea, abdominal cramps, nausea, increased salivation, miosis, increased bronchial secretions, worsening of bronchial asthma, fasciculations, muscle weakness, and diaphoresis
Edrophonium
Life-Threatening or Dangerous AEs
- Bradycardia – possibly leading to hypotension – is most common
Edrophonium
Weight Gain
- Unusual
Edrophonium
Sedation
- Unusual
Edrophonium
What to Do About AEs
- Give atropine to treat airway obstruction from bronchial secretions
Edrophonium
Best Augmenting Agents for AEs
- Not applicable
