Drugs Used in Disorders of the Endocrine System



Drugs Used in Disorders of the Endocrine System



Overview


The endocrine system has often been viewed as more complex than other physiologic systems, primarily because the target organ is usually located relatively far from the site of release of the chemical mediator of the signal. However, it is now recognized that the signaling mechanisms—which use enzymes, neurochemical transmitters, hormones, and receptors—are similar (aside from distance) to those of other systems. Hence, the basic pharmacologic principles of therapy are the same. Some of the major applications of these drugs include treatment of hypothalamic and pituitary disorders, thyroid dysfunctions, disorders involving adrenal corticosteroids, and diabetes.


Hypopituitarism may be partial or complete and may result from hypothalamic disease (leading to deficiency of hypothalamic-releasing hormones) or intrinsic pituitary disease (causing pituitary hormone deficiency). Hypopituitarism may affect any of these pituitary hormones: thyrotropin, growth hormone (GH), luteinizing hormone, follicle-stimulating hormone, and corticotropin (ACTH). In targeting one of these hormones, therapy for GH deficiency aims to restore normal body composition, as well as, in children, to promote linear growth. Therapy for acromegaly, caused by excessive GH secretion, includes surgery and/or radiation, or use of a GH inhibitor.


Hypothyroidism can result from either thyroid or hypothalamic dysfunction. The treatment of choice is hormone substitution by using a synthetic hormone. Hyperthyroidism (thyrotoxicosis) is characterized by increased metabolism, and the primary treatment options include surgery, radioactive iodine, or drugs that inhibit the formation of thyroid hormones, such as by blocking the utilization of iodine.


The principal functions of glucocorticoids involve regulation of carbohydrate metabolism and a variety of other physiologic actions. Synthetic corticosteroids (eg, hydrocortisone, prednisone, and dexamethasone) are widely used as therapeutic agents in treatment of cancer and autoimmune or inflammatory-type disorders. Pharmacologic treatment is also available for insufficient adrenal function, which is manifested as Addison disease, and excess glucocorticoid exposure, which results in Cushing syndrome.


Diabetes mellitus (DM) is a syndrome caused by a relative or absolute deficiency of insulin, with hyperglycemia being the hallmark medical finding. DM can occur as either an early onset form (type 1) or a gradual-onset form (type 2). In the former, insulin-producing β cells of the pancreas are destroyed or insufficiently active, and patients require lifelong treatment with exogenous insulin. In type 2 DM, adequate control of disease may be achieved by means of diet and exercise; if these methods fail, patients take oral hypoglycemic agents, which cause lower plasma glucose levels, improve insulin resistance, and reduce long-term complications (macrovascular and microvascular problems such as neuropathy, nephropathy, and retinopathy). Insulin is the sole treatment for type 1 DM and is sometimes also used for type 2 DM. For type 2 DM, drugs include sulfonylureas, which stimulate insulin secretion from pancreatic β cells; metformin, a biguanide that decreases blood glucose levels by reducing hepatic glucose production and glycogen metabolism in the liver and improving insulin resistance; meglitinides, which increase insulin secretion from pancreatic β cells; α-glucosidase inhibitors, which delay carbohydrate digestion and glucose absorption; and thiazolidinedione (TZD) derivatives (eg, rosiglitazone and pioglitazone), which reduce insulin resistance.











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Jun 21, 2016 | Posted by in PHARMACY | Comments Off on Drugs Used in Disorders of the Endocrine System

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