Drug therapy and poisoning

16 Drug therapy and poisoning



Questions




Question 1


How should the body surface area be calculated when giving drugs for which doses are given per square metre of body surface area?



Question 2


Where can I find a reference table that shows drugs that can safely be prescribed and avoided during pregnancy and during lactation? Might this be included in the next edition of Kumar and Clark’s Clinical Medicine?



Question 3


Where might I find a reference table showing paediatric drug doses?



Question 4


My question is concerned with the practical use of steroids. In inflammatory bowel disease, what doses are used and when is the dose reduced?



Question 5


What is the safe dosage/length of treatment for the drug dexmethasone so that its destructive effects are avoided?



Question 6



1. Please explain ‘odds ratio’ and ‘risk ratio’.

2. What is meant by saying that diabetics have a 3.3 risk ratio of developing dementia?


Question 7


I’m a medical student from the Faculty of Medicine, Peradeniya, Sri Lanka. I have a question about the management of aspirin poisoning. Is it reasonable to carry out a postalkaline diuresis in these patients?



Question 8


What is meant by intermediate syndrome in organophosphorus poisoning?



Question 9


What are the pulmonary manifestations of Pink’s disease and how common are they relative to the usual cerebral, skin and renal effects?



Question 10


Is it necessary to administer antivenom to a person bitten by a snake 6 hours previously, presenting only with local leg swelling over the bitten site and so far no other systemic feature of poisoning?



Question 11


What is the ideal management for scorpion bite?



Question 12


In acute anaphylaxis, you recommend IM adrenaline (epinephrine). Surely in such an acute situation intravenous adrenaline would be better?



Question 13


Why should patients avoid grapefruit juice if they are taking terfenadine?



Question 14


Many older drug therapies, e.g. penicillin in streptococcal sore throat, have never been submitted to rigorous trials such as a randomized controlled trial (RCT). Do you think they should be?



Question 15


Please explain why some drugs are teratogenic in the first trimester and some in the second?



Question 16


What is the difference between compliance and concordance?



Question 17


The rates of paracetamol (acetaminophen) self-poisoning have decreased in the UK. Why is this?



Question 18


Is N-acetylcysteine of any use in a case of paracetamol overdosage taken 16 hours previously?



Question 19


What is meant by primary end point and secondary end point?



Question 20


Can chronic exposure to organophosphorus compounds (in farmers) cause axonal radiculoneuropathy persisting for years? Is this disease reversible?


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Dec 4, 2016 | Posted by in GENERAL & FAMILY MEDICINE | Comments Off on Drug therapy and poisoning

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