Desmoplastic Fibroblastoma
Khin Thway, BSc, MBBS, FRCPath
Key Facts
Terminology
Rare benign fibrous soft tissue neoplasm occurring mainly in adult males and consisting of paucicellular arrays of stellate and spindle fibroblasts
Clinical Issues
Usually in older adults (5th to 6th decades)
Male preponderance
Most occur in subcutaneous tissue but up to 25% involve skeletal muscle
Most common in proximal extremity
Microscopic Pathology
Sparsely cellular patternless distributions of bland spindle or stellate cells
Hypovascular fibrous or fibromyxoid stroma
Mitotic figures rare; no necrosis
Ancillary Tests
Variably SMA(+)
 Hematoxylin & eosin shows desmoplastic fibroblastoma. The lesion is a well-circumscribed ovoid or fusiform mass. The hypocellularity is apparent at low power. |
 Hematoxylin & eosin shows desmoplastic fibroblastoma. Although most tumors are subcutaneous, some involve skeletal muscle  , which this lesion is seen to abut. |
TERMINOLOGY
Abbreviations
Desmoplastic fibroblastoma (DF)
Synonyms
Collagenous fibroma
Definitions
Rare benign fibrous soft tissue neoplasm occurring mainly in adult males and consisting of paucicellular arrays of stellate and spindle fibroblasts
Reciprocal translocation t(2;11)(q31;q12) found in some cases
ETIOLOGY/PATHOGENESIS
Developmental Anomaly
Etiology unknown
CLINICAL ISSUES
Epidemiology
Age
All ages, but particularly older adults (5th-6th decades)
Gender
M > F
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