Cough, dyspnoea and fever in a 55-year-old man

Problem 33 Cough, dyspnoea and fever in a 55-year-old man







You review the chest X-ray Figure 33.1 and the results of your other tests can be seen in Investigation 33.1.







You assess him as having moderately severe pneumonia. His age, his mental state and the multilobar involvement are high-risk characteristics requiring admission to hospital, and you arrange a bed in the respiratory unit.



The patient is placed on oxygen via nasal cannula at 4 L/min. An intravenous line is inserted and 1 L isotonic saline is set up running over 2 hours to rehydrate the patient. You check with the patient and his family to ensure he is not allergic to penicillin.


The nurse is kindly drawing up the antibiotics, and your IV fluids are running. His family have started asking you some questions.



The patient was commenced on erythromycin 1 g 6-hourly and ceftriaxone 1 g intravenously. He was rehydrated using isotonic saline so as not to exacerbate the hyponatraemia. The hypokalaemia was corrected.


Sputum culture on special medium was positive for Legionella pneumophila after 3 days. Urine was positive for legionella antigen (specific for L. pneumophila 1). Blood cultures were negative. His respiratory status was closely monitored with the assistance of oximetry and serial blood gases. Initial serology for Legionella species by indirect fluorescent antibody was <1 : 4. At 16 days the L. pneumophila titre was 1 : 1024. Intravenous erythromycin was continued for 7 days and an oral dose of clarithromycin 500 mg 12-hourly was given for a further 2 weeks.


He improved after 72 hours and made a slow recovery over the following 10 days. The disease was notified to the Department of Health and L. pneumophila was subsequently isolated from a sprinkler system in the patient’s greenhouses. The water system was decontaminated. The patient was told that his cigarette smoking and alcohol intake had put him at increased risk of contracting this illness. He was advised to stop smoking and was given options to assist with this process.



Answers


A.1 The presentation of this case strongly suggests community-acquired pneumonia. The patient has fever, cough, dyspnoea and abnormal respiratory signs but no hard clinical signs of consolidation. His respiratory rate is markedly increased, which is an important sign of respiratory compromise. Gastrointestinal symptoms (vomiting and diarrhoea) are not uncommon in pneumonia and may be misleading features for site of infection. Audible crackles on respiratory examination is a frequent and an important sign not to miss. Signs of consolidation is present in only about 30% of patients.


However, some patients can present with fever without localizing symptoms.


Pneumonia can also be referred to anatomically as in right lower lobe pneumonia or on the basis of aetiology such as pneumococcal pneumonia.


Differential diagnoses include pulmonary embolism, pulmonary vasculitis, malignacy, and hypersensitivity pneumonitis.


A.2 The following investigations are required to confirm diagnosis, assess severity and investigate for causative organism:


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Apr 2, 2017 | Posted by in GENERAL SURGERY | Comments Off on Cough, dyspnoea and fever in a 55-year-old man

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