Constipation is a common GI symptom that is defined as infrequent or difficult evacuation of stool. Every individual affected by constipation defines it differently, but normal defecation can vary from daily to three times a day or to every 3 days. Constipation can be a consequence of multiple factors, including diet, lifestyle, medications, and many disease states. In a systematic review of the epidemiology of constipation globally by Suares and Ford (2011), the mean prevalence of constipation in the general population was found to be 14%. Constipation affects 2.2 females to 1 male, and the incidence increases with age, especially in those over age 65. Sommers et al. (2011) report a 41.5% increase of emergency room visits and ambulatory care visits for constipation between 2006 and 2011. The incidence of constipation in children is reported between 0.7% and 29% worldwide with prevalence equal between boys and girls (Rajindrajith & Devanarayana, 2011). Dietary and lifestyle modifications are the preferred therapy for constipation, but many patients use over-the-counter (OTC) laxatives for relief. Americans spend over $290 million billion for OTC and prescription laxatives and over $7.5 billion dollars annually for treatment (Pomeranz et al., 2013). Most of these laxatives are considered safe and effective, but overuse or abuse may have serious consequences.