Author (years)
Ayuk et al. (2004)
Gruber et al. (2006)
Sibal et al. (2004)
Type of management
Conservative
Surgery
P
Conservative
Surgery
P
Conservative
Surgery
P
N
18
15
–
20
10
–
18
27
–
Mean age (year) (range)
NA
NA
–
54 (23–84)
46 (17–70)
–
45.7 (25–72)
50.7 (25–72)
NS
Male/female
NA
NA
–
16/4
7/3
–
9/9
19/8
At presentation
Number (%) with decreased visual acuity
NA
NA
–
11 (55)
7 (70)
–
4/15 (26)
14/24 (58)
0.01
Number (%) with visual field defect
6 (33)
7 (46)
ns
4 (20)
6 (60)
–
4/17 (24)
16/25 (64)
0.01
Number (%) with ocular palsy
7 (39)
8 (53)
ns
12 (60)
3 (37)
–
8/17 (47)
14/26 (54)
NS
Number (%) with hypopituitarism
13 (87)
15 (83)
ns
15 (75)
9 (90)
–
13/18 (72)
21/24 (87)
NS
Outcome
Decreased visual acuity
Complete resolution
NA
NA
–
5/11 (45)
4/7 (57)
–
3/4 (75)
8/14 (57)
–
Partial/near-complete resolution
NA
NA
–
4/11 (36)
2/7 (28)
–
1/4 (25)
5/14 (36)
–
No improvement
NA
NA
–
2/11 (19)
1/7 (15)
–
0
1/14 (7)
–
Visual field defect
Complete resolution
6/6 (100)
4/7 (57)
ns
2/4 (50)
2/6 (33)
–
3/4 (75)
7/16 (43)
–
Partial/near-complete resolution
0
NA
–
1/4 (25)
3/6 (50)
–
1/4 (25)
8/16 (50)
–
No improvement
0
NA
–
1/4 (25)
1/6 (17)
–
0
1/16 (7)
–
Ocular palsy
Complete
7/7 (100)
5/8 (63)
ns
10/12 (83)
2/3 (66)
–
6/8 (75)
9/14 (64)
–
Partial/near-complete resolution
0
NA
–
2/12 (17)
1/3 (33)
–
2/8 (25)
4/14 (29)
–
No improvement
0
NA
–
0
0
–
0
1/14 (7)
–
Endocrine impairment
Normal function
NA
NA
–
1 (5)
2 (20)
–
2 (11)
5 (19)
–
Corticotropic deficiency
13/18 (72)
13/15 (87)
ns
(68)
(60)
–
NA
NA
–
Thyrotropic deficiency
9/15 (60)
13/15 (87)
ns
(70)
(68)
–
NA
NA
–
Gonadotropic deficiency
15/18 (83)
10/15 (67)
ns
(80)
(86)
–
NA
NA
–
Tumor growth
Recurrence of pituitary adenoma
1 (5)
1 (6)
–
0
6 (60)
–
4 (22)
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