Condyloma, Anus
Scott R. Owens, MD
Key Facts
Etiology/Pathogenesis
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Sexually transmitted disease
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HPV serotypes 6, 11 most common in anal condylomata
Clinical Issues
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Increasing incidence (˜ 50% over past several decades)
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Most common in adults; can occur at any age
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Can be associated with other HPV infection-related pathology
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May affect anal transition zone or perianal skin
Microscopic Pathology
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Characteristic cells with viral effect (koilocytes) seen histologically
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Reactive epithelial atypia possible in inflamed lesions
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Squamous epithelium matures normally
Hematoxylin & eosin shows a low-power view of an anal condyloma. Note the papillomatous growth pattern and attachment  to perianal skin. |
Hematoxylin & eosin shows several koilocytes  indicative of HPV infection. Note the characteristic perinuclear halos surrounding irregularly contoured nuclei  . |
TERMINOLOGY
Synonyms
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Anogenital wart
Definitions
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Squamous papilloma caused by infection with human papillomavirus (HPV)
ETIOLOGY/PATHOGENESIS
Infectious Agents
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HPV
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Sexually transmitted disease
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Most frequently seen in patients who engage in anal intercourse
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Several HPV serotypes commonly found (1, 2, 6, 7, 10, 11, 16, 18)
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6, 11 most common in anal condylomata
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16, 18 associated with squamous dysplasia/anal intraepithelial neoplasia
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CLINICAL ISSUES
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