Clinical immunology

3 Clinical immunology



Questions




Question 1


Please could you explain how lymphocytes (especially B) can maintain receptors on their surfaces? Is this genetically related? If so, when the lymphocytes are first exposed to the antigens, how could the antigen receptor be synthesized?


Is there a mutation within the nuclei of these lymphocytes when they learn to make the receptors? If there is, can you explain how this occurs?



Question 2


I understand how nuclear factor-κB (NFκB) works in the inflammatory response but what is the mechanism by which it causes cancer?



Question 3


What are the diseases associated with hypocomplementaemia and which complement deficiency in particular?



Question 4


What is meant by ‘B lymphocytes are sensitive to clonal deletion’?



Question 5


What are the immunological implications of ‘bare lymphocyte syndrome’/MHC deficiency?



Question 6


Please explain oligoclonal and monoclonal.



Question 7


I was wondering if there is any study regarding cell culture techniques of CD4 helper cells (stem cell culturing) and, if so, is it of any benefit to HIV-infected patients?



Question 8


How do you define autoimmune disease?



Question 9



1. Why is dexamethasone not routinely used instead of prednisolone, which is almost universally used routinely in autoimmune diseases, or other indications for steroids? Is it because dexamethasone lacks the mineralocorticoid activity seen with prednisolone and therefore does not cause salt/water retention and hypertension?

2. Can high doses of dexamethasone be used in acute relapses of multiple sclerosis (MS) in place of pulse methylprednisolone? If so, what is the recommended dosage?


Question 10


What is meant by ‘pus cell’ and is this term synonymous with neutrophils?



Question 11


Can dendritic cells migrate into lymph nodes? Immunology textbooks state that these initial blood monocytes infiltrate inflamed tissue. Is the professional antigen-presenting cell the dendritic cell that enters lymph nodes?

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Dec 4, 2016 | Posted by in GENERAL & FAMILY MEDICINE | Comments Off on Clinical immunology

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