Clinical Decision Making

Chapter 2 Clinical Decision Making




Clinical Case Problem 1 A Third-Year Medical Student Who Wants to Know How to Think


A third-year medical student asks you to teach her the secrets of clinical decision making, or how you think when you approach and treat a patient. You agree to take her to see a patient in the emergency department. After you talk with the patient, you ask the student to describe everything she has seen and heard. You carefully note that she has missed approximately half of what happened in the conversation between you and the patient and even more in the physical examination.




Clinical Case Problem 2 A 25-Year-Old Medical Student Who Is Having Anxiety Regarding His Upcoming Epidemiology Examination


A 25-year-old medical student comes to your office in a state of extreme anxiety manifested by palpitations and sweating throughout the previous week. He tells you he is scheduled to have a clinical epidemiology examination in 24 hours.


On physical examination, his blood pressure is 120/70   mm Hg, pulse is 90 beats per minute and regular, and respirations are 24 per minute. His physical examination is normal. You order a thyroid-stimulating hormone test to exclude hyperthyroidism. You explain to him that given the low prevalence of thyroid disease in his age group and the higher prevalence of anxiety in his medical school population of students, the test’s negative predictive value will be helpful. He looks confused and more anxious.


In an attempt to deal with his symptoms, you decide to spend some time tutoring the student in basic epidemiologic concepts. You begin by explaining the basics of a 2 × 2 table that relates positive and negative test results to the presence or absence of disease in a specific population (Table 2-1).


Table 2-1 Relationship Between Test A and Disease B















  Disease B Present Disease B Absent
Test A result positive 30 50
Test A result negative 10 80

Use the data from Table 2-1 for questions 4 to 9.



Consider the data in Table 2-2 illustrating the prevalence of disease X in various populations. On the basis of this information about disease prevalence and assuming the sensitivity of test A for disease X is 80% and the specificity of test A for disease X is 90%, answer questions 10 to 13.



Table 2-2 Prevalence of Disease X in Certain Populations















Setting Prevalence (Cases/100,000)
General population               50
Women, ≥50 years        500
Women, ≥65 years, with a suspicious finding on clinical examination 40,000

To answer question 14, consider the data in Table 2-3 regarding the sensitivity and specificity in the diagnosis of diabetes mellitus in the population.



Table 2-3 Sensitivity and Specificity of Blood Glucose Levels in the Diagnosis of Diabetes Mellitus











Blood Glucose Levels 2 Hours after Eating Sensitivity Specificity
>140   mg/100 (7.8   mmol/L) 57% 99.4%

Consider the following experimental data: In a trial of the effect of reducing multiple risk factors on the subsequent incidence of coronary artery disease, high-risk patients were selected for study. Elevated blood pressure was one of the risk factors for people to be considered. People were screened for inclusion in the study on three consecutive visits. Blood pressures at those visits, before any therapeutic interventions were undertaken, were as listed in Table 2-4. Use the data in Table 2-4 to answer question 18.



Table 2-4 Blood Pressure Readings versus Visit Number















Visit Number Mean Diastolic Blood Pressure (mm Hg)
1 99.2
2 91.2
3 90.7

Consider the following experimental data: A population of heavy smokers (men smoking more than 50 cigarettes per day) are divided into two groups and observed for a period of 10 years.


Use the data from Table 2-5 to answer question 19.


Oct 1, 2016 | Posted by in GENERAL SURGERY | Comments Off on Clinical Decision Making

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