Chapter 2 Clinical Decision Making
Clinical Case Problem 1 A Third-Year Medical Student Who Wants to Know How to Think
Select the best answer to the following questions
1. This case represents a problem with which step(s) of the clinical decision making process?
2. The most common problem related to clinical decision making by practicing physicians is
3. The student returns with you to the office and sees a patient on her own initially to gather historical and physical examination data, which she then presents to you. After seeing the patient, she is absolutely convinced the patient has a particular diagnosis. You take her with you to see the patient, and you obtain more historical information and examine the patient. As you ask her questions about her reasoning, she proceeds to ignore a whole variety of things that do not support her original diagnostic hypothesis. She has made which of the following errors in clinical decision making?
Clinical Case Problem 2 A 25-Year-Old Medical Student Who Is Having Anxiety Regarding His Upcoming Epidemiology Examination
In an attempt to deal with his symptoms, you decide to spend some time tutoring the student in basic epidemiologic concepts. You begin by explaining the basics of a 2 × 2 table that relates positive and negative test results to the presence or absence of disease in a specific population (Table 2-1).
Disease B Present | Disease B Absent | |
---|---|---|
Test A result positive | 30 | 50 |
Test A result negative | 10 | 80 |
Use the data from Table 2-1 for questions 4 to 9.
4. What is the sensitivity of test A for disease B?
5. What is the specificity of test A for disease B?
6. What is the positive predictive value (PPV) of test A in the diagnosis of disease B?
7. What is the negative predictive value (NPV) of test A in the diagnosis of disease B?
8. What is the likelihood ratio for test A in disease B?
9. What is the prevalence of disease A in this population?
Consider the data in Table 2-2 illustrating the prevalence of disease X in various populations. On the basis of this information about disease prevalence and assuming the sensitivity of test A for disease X is 80% and the specificity of test A for disease X is 90%, answer questions 10 to 13.
10. What is the PPV of test A in the diagnosis of disease X in the general population?
11. What is the PPV of test A in disease X in women aged 50 years or older?
12. What is the PPV of test A in disease X in women older than 65 years with a suspicious finding on clinical examination?
13. If the PPV of a test for a given disease in a given population is 4%, how many true positive test results are there in a sample of 100 positive test results?
Setting | Prevalence (Cases/100,000) |
---|---|
General population | 50 |
Women, ≥50 years | 500 |
Women, ≥65 years, with a suspicious finding on clinical examination | 40,000 |
To answer question 14, consider the data in Table 2-3 regarding the sensitivity and specificity in the diagnosis of diabetes mellitus in the population.
14. Given that the data are correct, if the sensitivity of the test for a given blood glucose level is 36%, which of the following would be the most likely value for specificity?
15. The validity of a test is best defined as which of the following?
16. Which of the following terms is synonymous with the term reliability?
17. Which of the following is not a measure of central tendency?
Blood Glucose Levels 2 Hours after Eating | Sensitivity | Specificity |
---|---|---|
>140 mg/100 (7.8 mmol/L) | 57% | 99.4% |
Consider the following experimental data: In a trial of the effect of reducing multiple risk factors on the subsequent incidence of coronary artery disease, high-risk patients were selected for study. Elevated blood pressure was one of the risk factors for people to be considered. People were screened for inclusion in the study on three consecutive visits. Blood pressures at those visits, before any therapeutic interventions were undertaken, were as listed in Table 2-4. Use the data in Table 2-4 to answer question 18.
18. Which of the following statements regarding these data is true?
Visit Number | Mean Diastolic Blood Pressure (mm Hg) |
---|---|
1 | 99.2 |
2 | 91.2 |
3 | 90.7 |
Use the data from Table 2-5 to answer question 19.