Central Odontogenic Fibroma
Brenda L. Nelson, DDS, MS
Key Facts
Terminology
Rare, benign, odontogenic neoplasm of inactive-appearing odontogenic epithelium embedded in mature fibrous stroma
Etiology/Pathogenesis
Considered to be of periodontal ligament origin
Clinical Issues
Wide age range
Female > Male (3:1)
Microscopic Pathology
Well-circumscribed, yellow-white cut surface
Collagen stroma, dense to myxoid
Odontogenic epithelium may or may not be present
Cementum or dentin-like calcifications
Dystrophic calcifications
Top Differential Diagnoses
Dental follicle, desmoplastic fibroma, myxofibroma
 This central odontogenic fibroma has a loose stroma with fine collagen fibrils and small odontogenic epithelial rests  . Odontogenic rests are not always seen. |
 Dense fibrous stroma with a vague whorling pattern and focal calcifications  are characteristic of the variant referred to as the WHO type. This subclassification is being phased out. |
TERMINOLOGY
Abbreviations
Central odontogenic fibroma (COF)
Definitions
Benign odontogenic neoplasm showing varying amounts of inactive-appearing odontogenic epithelium embedded in mature fibrous stroma
ETIOLOGY/PATHOGENESIS
Pathogenesis
Most are considered to be of periodontal ligament origin
Dental follicle may be consideration
Peripheral odontogenic fibroma is soft tissue counterpart
CLINICAL ISSUES
Epidemiology
Incidence
Uncommon
Age
Wide range
