Cellular Blue Nevi



Cellular Blue Nevi


Soheil Sam Dadras, MD, PhD

Olubukola Babalola





Key Facts


Terminology



  • Cellular variant of blue nevus


Clinical Issues



  • Occurs in children and young adults


  • Heavily pigmented black/blue nodule or plaque ranging from 1-2 cm; tends to occur on buttocks and sacrococcygeal region


  • Has low incidence of transformation into melanoma


Microscopic Pathology



  • Dumbbell-shaped architecture


  • Oval and spindle-shaped cells with bland cytology


  • Lack of mitoses or necrosis


Top Differential Diagnoses



  • Atypical cellular blue nevus


  • Melanoma developing in cellular blue nevus and malignant blue nevus


  • Desmoplastic melanoma







Scanning magnification of a CBN shows symmetrical hypercellular lobules resembling “dumbbells” image. These nodules push evenly and deeply beyond the reticular dermis into the subcutis image.






High-power examination of a hypercellular fascicle shows oval-to-spindled cells; when cut en face, these cells appear more cuboidal image. There are few scattered melanophages image.


TERMINOLOGY


Abbreviations



  • Cellular blue nevus (CBN)

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Jul 8, 2016 | Posted by in PATHOLOGY & LABORATORY MEDICINE | Comments Off on Cellular Blue Nevi

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