Benign and Malignant Mesenchymal Tumors of the Liver Rondell P. Graham, MBBS Andrew L. Folpe, MD 26.1 INTRODUCTION Mesenchymal tumors of the liver can be challenging because they are not…

Pediatric Liver Tumors Saba Yasir, MBBS 25.1 HEPATOBLASTOMA Definition Hepatoblastomas are malignant epithelial neoplasms that are primary to the liver and show a range of hepatocellular differentiation, recapitulating various stages…

Imaging of Liver Tumors Michael L. Wells, MD Sudhakar K. Venkatesh, MD Radiologic evaluation represents a critical component of liver tumor detection and characterization. After discovery of a liver mass,…

Molecular Genetics of Liver Diseases Rondell P. Graham, MBBS 23.1 INTRODUCTION Molecular techniques are increasingly used in the characterization of diseases and specimens in clinical practice and research. These scientific…

Cytopathology of the Liver Yajue Huang, MD Andrea Jones, MD Michael Rivera, MD 22.1 INTRODUCTION Fine needle aspiration (FNA) is a commonly used approach to determine the nature of a…

Vascular Disorders Lizhi Zhang, MD 21.1 INTRODUCTION The liver has a dual blood supply. The portal vein provides approximately two-thirds of blood flow to the liver, with blood that is…

Transplantation Pathology Roger K. Moreira, MD Douglas A. Simonetto, MD 20.1 OVERVIEW Chronic liver disease is a major cause of morbidity and mortality worldwide. In the United States alone, nearly…

Liver Involvement in Systemic Diseases Lizhi Zhang, MD 19.1 INTRODUCTION Just as primary liver disease can affect other organ systems in the body, the liver may be affected in many…

Wilson Disease and Other Inherited Metabolic Diseases of Liver Lizhi Zhang, MD 18.1 INTRODUCTION Metabolic dysfunction of liver can be due to several causes. Congenital deficiency of a specific enzyme…

Iron Overload and Liver Pathology Vishal S. Chandan, MD Michael S. Torbenson, MD 17.1 INTRODUCTION The medical community has recognized that iron accumulation causes liver disease for several hundred years,…