T-Cell Prolymphocytic Leukemia
T-Cell Prolymphocytic Leukemia Alejandro A. Gru DEFINITION T-cell prolymphocytic leukemia (T-PLL) is a mature neoplasm of T cells with peripheral blood involvement. It is the most common subtype of mature…
PATHOLOGY & LABORATORY MEDICINE
Systemic Anaplastic Large Cell Lymphoma
Systemic Anaplastic Large Cell Lymphoma Alejandro A. Gru DEFINITION Anaplastic lymphoma kinase positive (ALK+) anaplastic large cell lymphoma (ALCL) is a mature T-cell lymphoma with expression of CD30 and ALK1…
Hydroa Vacciniforme and Hydroa Vacciniforme–Like Lymphoma
Hydroa Vacciniforme and Hydroa Vacciniforme–Like Lymphoma Andy C. Hsi Carlos Barrionuevo-Cornejo DEFINITION Hydroa vacciniforme (HV) is a rare, intermittent ultraviolet (UV) light–induced vesiculopapular and scarring eruption in children associated with…
Extranodal NK/T-Cell Lymphoma, Nasal-Type
Extranodal NK/T-Cell Lymphoma, Nasal-Type Carlos Barrionuevo-Cornejo DEFINITION Extranodal NK/T-cell lymphoma, nasal-type (ENKTL) is an aggressive, extranodal necrotizing tumor associated with Epstein–Barr virus (EBV) infection. ENKTL invariably presents in the nasal…
Aggressive Cytotoxic Cutaneous T-Cell Lymphomas
Aggressive Cytotoxic Cutaneous T-Cell Lymphomas Ellen J. Kim Jacqueline M. Junkins-Hopkins INTRODUCTION Cytotoxic cutaneous T-cell lymphomas (CTCLs) are extremely rare non–mycosis fungoides (MF) cutaneous T-cell or natural killer (NK)-cell lymphomas…
Primary Cutaneous Peripheral T-Cell Lymphoma, Not Otherwise Specified
Primary Cutaneous Peripheral T-Cell Lymphoma, Not Otherwise Specified Andy C. Hsi Amy C. Musiek András Schaffer DEFINITION Peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS) includes a heterogeneous group of non-Hodgkin…
Subcutaneous Panniculitis-Like T-Cell Lymphoma
Subcutaneous Panniculitis-Like T-Cell Lymphoma Alejandro A. Gru Kenneth Carson DEFINITION Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is a mature T-cell lymphoma of the skin with T-cell receptor (TCR) αβ expression, subcutaneous…
Primary Cutaneous CD4+ Small/Medium T-Cell Lymphoma
Primary Cutaneous CD4+ Small/Medium T-Cell Lymphoma Sanam Loghavi Michael T. Tetzlaff DEFINITION As its name implies, primary cutaneous small/medium CD4+ T-cell lymphoma is a cutaneous T-cell lymphoma confined to the…
Primary Cutaneous CD30+ T-Cell Lymphoproliferative Disorders
Primary Cutaneous CD30+ T-Cell Lymphoproliferative Disorders Rebecca L. King Amy C. Musiek Andrew L. Feldman INTRODUCTION Primary cutaneous CD30+ T-cell lymphoproliferative disorders (TLPDs) are challenging to both pathologists and clinicians…
Sézary Syndrome
Sézary Syndrome Ellen J. Kim András Schaffer DEFINITION Sézary syndrome (SS) is a rare subtype of cutaneous T-cell lymphoma (CTCL) that is closely related to, but not identical to, mycosis…
