Mononuclear Phagocytes of the Skin
Mononuclear Phagocytes of the Skin Sena J. Lee András Schaffer INTRODUCTION The mononuclear phagocyte system (MPS) is composed of at least three subsets of tissue histiocytes including monocytes, macrophages, and…
PATHOLOGY & LABORATORY MEDICINE
NK Cell Immunobiology
NK Cell Immunobiology Aharon G. Freud INTRODUCTION Natural killer (NK) cells are innate lymphoid cells (ILCs) that have a characteristic large granular lymphocyte morphology and that are able to recognize…
Cutaneous B-Cell Immunobiology
Cutaneous B-Cell Immunobiology Alejandro A. Gru INTRODUCTION Originally termed skin-associated lymphoid tissue (SALT), the “skin immune system” (SIS) comprises specialized skin-resident immune cells, as well as immunocompetent skin-trophic lymphocytes constantly…
Cutaneous T-Cell Immunobiology
Cutaneous T-Cell Immunobiology Andy C. Hsi András Schaffer INTRODUCTION The skin is the largest organ of the human body and functions as a physical and immunologic barrier against external pathogens…
Other Infections of the Liver
Other Infections of the Liver Michael S. Torbenson, MD 10.1 INTRODUCTION This chapter discusses nonviral and nonparasitic infections of the liver, though infections that are primarily granulomatous are discussed with…
Viral Hepatitis
Viral Hepatitis Roger K. Moreira, MD Douglas A. Simonetto, MD 8.1 GRADING AND STAGING OVERVIEW In a fashion somewhat analogous to tumor pathology—where grade refers to features that reflect disease…
Electron Microscopy
Electron Microscopy Taofic Mounajjed, MD 5.1 INTRODUCTION The rise of immunohistochemical, molecular, and serologic techniques in pathology over the past decades has somewhat sidelined certain diagnostic uses of the more…
Basic Patterns of Injury in Medical Liver Pathology
Basic Patterns of Injury in Medical Liver Pathology Roger K. Moreira, MD A pattern of injury represents individual histologic findings that cluster into a meaningful and recognizable histologic pattern. Identification…
Metastatic Tumors in the Liver
Metastatic Tumors in the Liver Lizhi Zhang, MD 31.1 INTRODUCTION The liver is one of the most common organs involved by metastases. In fact, metastatic tumors are the most common…
Hematopathology and the Liver
Hematopathology and the Liver Michael S. Torbenson Ellen D. McPhail 30.1 OVERVIEW The liver can be involved by reactive lymphoid hyperplasia and by various hematological malignancies. The appropriate diagnosis can…
