Cutaneous Plasma Cell Neoplasms Liaqat Ali Jozef Malysz INTRODUCTION Plasma cell neoplasms (PCN) include a spectrum of diseases that ranges from clinically indolent entities, such as monoclonal gammopathy of unknown…

Cutaneous Manifestations of Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma Alejandro A. Gru DEFINITION Chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) is the most common adult leukemia in Europe and North America, with…

Cutaneous Mantle Cell Lymphoma Alejandro A. Gru DEFINITION Mantle cell lymphoma (MCL) is a B-cell non-Hodgkin lymphoma (NHL) that comprises approximately 3% to 10% of the systemic B-cell NHL.1,2,3,4 It…

Cutaneous Involvement in Systemic Diffuse Large B-Cell Lymphomas Alejandro A. Gru DEFINITION The overall landscape of systemic B-cell lymphomas with a large-cell component has undergone major changes in the most…

Intravascular Large B-Cell Lymphoma Alejandro A. Gru DEFINITION Intravascular large B-cell lymphoma (IVLBCL) is a rare subtype of extranodal large B-cell lymphoma characterized by the confinement of lymphoma cells within…

Systemic Follicular Lymphoma, Marginal Zone Lymphomas, and Waldenström Macroglobulinemia Alejandro A. Gru FOLLICULAR LYMPHOMA Definition Systemic follicular lymphoma (sFL) is the most common subtype of non-Hodgkin lymphomas (NHL), accounting for…

Lymphomatoid Granulomatosis Alejandro A. Gru DEFINITION Lymphomatoid granulomatosis (LyG) is a rare angiocentric and angiodestructive Epstein–Barr virus (EBV)-associated B-cell lymphoproliferative disorder (LPD) with a predilection for the lung, central nervous…

Cutaneous Diffuse Large B-Cell Lymphomas Alejandro A. Gru DEFINITION The WHO defines diffuse large B-cell lymphoma, leg type (DLBCL-LT), as a malignant neoplasm of intermediate aggressive behavior, occurring most frequently…

Primary Cutaneous Marginal Zone B-Cell Lymphoma Katalin Ferenczi DEFINITION Primary cutaneous marginal zone B-cell lymphomas (PCMZLs) are indolent low-grade B-cell lymphomas of the skin. PCMZLs have been regarded as the…

Primary Cutaneous Follicle-Center B-Cell Lymphoma Michi M. Shinohara DEFINITION Primary cutaneous follicle-center B-cell lymphoma (PCFCL) is a neoplastic proliferation of germinal center B cells in the skin. PCFCL is one…