The concept of fibrohistiocytic neoplasms has been challenged largely because the malignant forms (i.e., malignant fibrous histiocytoma) consistently lack histiocytic features, and because some, when carefully studied, show a subtle…

Although previously grouped together in this textbook, superficial and deep fibromatoses are now discussed separately because of distinct differences in clinical behavior. The superficial fibromatoses are described with the benign…

Leiomyosarcomas account for 5% to 10% of soft tissue sarcomas. They are principally tumors of adults but are far outnumbered even in this age group by more common sarcomas, such…

Striated Muscle Tissue: Development and Structure Skeletal muscle is formed primarily within myotomes, which are arranged in segmental pairs along the spine and make their first appearance in the cephalic…

Fibrohistiocytic tumors of intermediate malignancy originally included only dermatofibrosarcoma protuberans and the closely related giant cell fibroblastoma. This category now embraces other lesions, such as plexiform fibrohistiocytic tumor and soft…

Immunohistochemistry (IHC) is the use of antibody-based reagents for localization of specific epitopes in tissue sections. Over the past several decades, IHC has become a powerful tool to assist the…

Fibrous tumors of infancy and childhood can be divided into two large groups: (1) lesions that correspond to similar lesions in adults in terms of clinical setting, microscopic picture, and…

Over the past several decades, remarkable advances have been seen in the use of imaging for diagnosing, staging, and following up cases of soft tissue neoplasms. In this chapter we…

Acknowledgments An apology is extended to those colleagues whose papers could not be cited because of space considerations. Human neoplasms display a wide variety of genetic alterations, most of which…