(FDA approved in bold)

• Acute painful musculoskeletal conditions
  
• Muscle spasm
  
• Insomnia

• Sedative, may block interneuronal activity in the descending reticular formation and spinal cord

• Pain – as little as 30 minutes

• Titrate to most effective tolerated dose

• Increase dose. If ineffective, consider alternative medications

• Botulinum toxin is effective, especially as an adjunct for focal spasticity, i.e., post-stroke or head injury affecting the upper limbs
  
• Use other centrally acting muscle relaxants with caution due to potential additive CNS depressant effect

• None required