Calcifying Aponeurotic Fibroma
Elizabeth A. Montgomery, MD
Key Facts
Terminology
Lesion consisting of spindled fibroblasts, epithelioid mesenchymal cells, and chondroid foci ± mineralization
Typically arises in hands and feet of children
Clinical Issues
Male predominance
Median age: 11-12 years
Most arise in 1st decade of life
Prone to local recurrences
Microscopic Pathology
Fibrous growth with multiple extensions into surrounding tissue
Centrally located zones of cartilage formation and stippled calcification
Mitoses scarce
 Hematoxylin & eosin shows a classic pediatric calcifying aponeurotic fibroma. There are rounded to spindled cells around islands of poorly delineated matrix, which is focally calcified  . |
 Hematoxylin & eosin shows a higher magnification view. A few giant cells can been seen  . |
TERMINOLOGY
Synonyms
Keasbey tumor
Juvenile aponeurotic fibroma
Calcifying fibroma
Definitions
Lesion consisting of spindled fibroblasts, epithelioid mesenchymal cells, and chondroid foci ± mineralization
Typically arises in hands and feet of children
CLINICAL ISSUES
Epidemiology
Incidence
Rare: < 150 examples available in Armed Forces Institute of Pathology repository
Age
Stay updated, free articles. Join our Telegram channel
Full access? Get Clinical Tree
