Benign Fibroblastic Polyp/Perineurioma
Elizabeth A. Montgomery, MD
Key Facts
Terminology
Colonic mucosal proliferation of monomorphic spindle cells leading to separation, entrapment, and disorganization of colonic crypts
Morphologically identical lesions variably express markers of perineurial differentiation
Hence paired terminology above
Clinical Issues
Reported cases detected incidentally, typically at time of routine colonoscopy screening for colorectal adenomas
No gender predilection
Median age: 50-55 years
Median size: 3 mm
Often associated with serrated polyps of various types
 Hematoxylin & eosin shows a benign fibroblastic polyp of the colon. The lesion has its epicenter in the lamina propria and essentially no inflammatory component. |
 Hematoxylin & eosin shows high magnification of a colonic benign fibroblastic polyp. The cells are bland with small nuclei. Compare them to the size of the erythrocytes as an internal control. |
TERMINOLOGY
Abbreviations
Benign fibroblastic polyp/perineurioma (BFP)
Definitions
Colonic mucosal proliferation of monomorphic spindle cells leading to separation, entrapment, and disorganization of colonic crypts
Morphologically identical lesions variably express markers of perineurial differentiation,
Hence paired terminology above
CLINICAL ISSUES
Epidemiology
Age
Median: 50-55 years
Gender
No predilection
Presentation
Reported cases detected incidentally, typically at time of routine colonoscopy screening for colorectal adenomas
Median size: 3 mm
Often associated with serrated polyps of various types
Treatment
Polypectomy
