Immunocytology
Immunocytology, or immunocytochemistry (ICC), involves the use of ICC in diagnostic cytopathology. The application of immunostains in cytology cases has expanded and improved our ability to make definitive and accurate…
Immunohistology of Pancreas and Hepatobiliary Tract
In the ensuing chapter, the cellular lineage markers and the application of immunohistochemistry (IHC) in the diagnosis and management of specific tumor types are reviewed. We feel obliged to provide…
Imaging and Quantitative Immunohistochemistry
Overview Pathologists frequently use immunohistochemistry (IHC) to evaluate antigen location and expression patterns in tissue for diagnostic and/or prognostic purposes. This process often also requires quantification of these immunostains to…
Immunohistology of the Gastrointestinal Tract
This chapter divides the discussion of immunohistochemistry (IHC) of the luminal gastrointestinal (GI) tract into three sections: (1) epithelial pathology, (2) neuroendocrine lesions, and (3) spindle cell lesions. We have…
Immunohistology of the Prostate
Chapter Outline Overview, 588 Biology of Antigens and Antibodies, 588 Diagnostic Immunohistochemistry of Specific Prostate Lesions, 591 Beyond Immunohistochemistry: Theranostic and Genomic Applications, 608 Summary, 623 Overview Used in the…
Immunohistology of the Bladder, Kidney, and Testis
Overview The unprecedented advances in cancer genetics and genomics are rapidly affecting the clinical management of solid tumors. Molecular diagnostics are now an integral part of routine clinical management for…
Immunohistology of Skin Tumors
Overview The skin is a complex microenvironment. The normal structures of the epidermis, dermis, and cutaneous adnexa are morphologically and functionally complicated, and the histologic entities that occur in this…
Immunohistology of Lymph Node and Lymph Node Neoplasms
Only a little more than 30 years ago a popular, widely used classification system for non-Hodgkin lymphomas was initiated based solely on hematoxylin and eosin (H&E)–stained slide interpretation. The “Working…
Immunohistology of Carcinoma of Unknown Primary Site
The impact of diagnostic immunohistochemistry (IHC) for the surgical pathologist is legendary, and it is best appreciated when studying malignancies of unknown primary site. A cost-effective tool, IHC is performed…
Immunohistology of Melanocytic Neoplasms
Overview Melanoma continues to represent one of the greatest diagnostic challenges in surgical pathology and is an important source of litigation. Both as a primary lesion in the skin and…
