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Angiosarcoma, Atypical Vascular Lesions Following Irradiation, and Kaposi Sarcoma

May 10, 2026 by drzezo in PATHOLOGY & LABORATORY MEDICINE Comments Off on Angiosarcoma, Atypical Vascular Lesions Following Irradiation, and Kaposi Sarcoma

Angiosarcoma Angiosarcomas are malignant tumors that recapitulate many of the functional and morphologic features of normal endothelium. They vary from highly differentiated tumors resembling a hemangioma to anaplastic lesions difficult…

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Benign Tumors Showing Smooth Muscle Differentiation

May 10, 2026 by drzezo in PATHOLOGY & LABORATORY MEDICINE Comments Off on Benign Tumors Showing Smooth Muscle Differentiation

Leiomyomas Background To a large extent, the distribution of benign smooth muscle tumors parallels the distribution of smooth muscle tissue in the body. The tumors tend to be relatively common…

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Skeletal Muscle Tumors: Benign and of Borderline Malignancy

May 10, 2026 by drzezo in PATHOLOGY & LABORATORY MEDICINE Comments Off on Skeletal Muscle Tumors: Benign and of Borderline Malignancy

Striated Muscle Tissue: Development and Structure Skeletal muscle is formed primarily within myotomes, which are arranged in segmental pairs along the spine and make their first appearance in the cephalic…

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Benign Fibrohistiocytic Tumors

May 10, 2026 by drzezo in PATHOLOGY & LABORATORY MEDICINE Comments Off on Benign Fibrohistiocytic Tumors

The term “fibrohistiocytic” is descriptive and merely denotes a lesion composed of cells that resemble normal histiocytes and fibroblasts. Benign fibrohistiocytic tumors, however, are a pathogenetically diverse group of lesions….

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Fibrohistiocytic Tumors of Intermediate Malignancy

May 10, 2026 by drzezo in PATHOLOGY & LABORATORY MEDICINE Comments Off on Fibrohistiocytic Tumors of Intermediate Malignancy

The category of “fibrohistiocytic tumors of intermediate malignancy” originally included only dermatofibrosarcoma protuberans and the closely related giant cell fibroblastoma. This category now embraces other lesions, such as plexiform fibrohistiocytic…

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Immunohistochemistry for Analysis of Soft Tissue Tumors

May 10, 2026 by drzezo in PATHOLOGY & LABORATORY MEDICINE Comments Off on Immunohistochemistry for Analysis of Soft Tissue Tumors

Introduction Immunohistochemistry (IHC) is the use of antibody-based reagents for localization of specific epitopes in tissue sections. Over the past several decades, IHC has become a powerful tool to assist…

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Benign Fibroblastic/Myofibroblastic Neoplasms and Proliferations, Including Superficial Fibromatoses

May 10, 2026 by drzezo in PATHOLOGY & LABORATORY MEDICINE Comments Off on Benign Fibroblastic/Myofibroblastic Neoplasms and Proliferations, Including Superficial Fibromatoses

Fibrous connective tissue consists principally of fibroblasts and an extracellular matrix (ECM) containing fibrillary structures (collagen, elastin) and nonfibrillary ECM, or ground substance. Dense fibrous connective tissue, such as that…

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Borderline and Malignant Fibroblastic/Myofibroblastic Tumors

May 10, 2026 by drzezo in PATHOLOGY & LABORATORY MEDICINE Comments Off on Borderline and Malignant Fibroblastic/Myofibroblastic Tumors

Although previously grouped together in this textbook, superficial and deep fibromatoses are now discussed separately because of distinct differences in clinical behavior. The superficial fibromatoses are described along with other…

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Radiologic Evaluation of Soft Tissue Tumors

May 10, 2026 by drzezo in PATHOLOGY & LABORATORY MEDICINE Comments Off on Radiologic Evaluation of Soft Tissue Tumors

Over the past several decades, remarkable advances have occurred in imaging for diagnosis, staging, assessing treatment response, and surveillance of soft tissue tumors. In this chapter we discuss the multimodality…

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Fibrous Tumors of Infancy and Childhood

May 10, 2026 by drzezo in PATHOLOGY & LABORATORY MEDICINE Comments Off on Fibrous Tumors of Infancy and Childhood

Fibrous tumors of infancy and childhood can be divided into two large groups: (1) lesions that correspond to similar lesions in adults in terms of clinical setting, microscopic picture, and…

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