apomorphine

Class




  • Dopamine agonist, non-ergot




Apomorphine


Commonly Prescribed for


(FDA approved in bold)



  • Parkinson’s disease (PD): acute intermittent treatment of “off” episodes



Apomorphine


How the Drug Works



  • Dopamine agonist, with high affinity for the D2 receptor. This action is likely the main reason for effectiveness in PD



Apomorphine


How Long Until It Works



  • PD – 10–60 minutes



Apomorphine


If It Works



  • PD – this is an adjunctive medication designed for use with other PD treatments. Continue to adjust other PD treatments to achieve maximum functionality



Apomorphine


If It Doesn’t Work



  • PD – adjust PD medication regimen, determine compliance with medications and reconsider the diagnosis



Apomorphine


Best Augmenting Combos for Partial Response or Treatment-Resistance



  • Patients requiring frequent injections will need an improved treatment plan to avoid severe “off” periods. Strategies include shortening the interval of levodopa dosing, adding COMT inhibitors, or adding longer-acting dopamine agonists



Apomorphine


Tests



  • None required



Adverse Effects (AEs)




Apomorphine


How Drug Causes AEs



  • Direct effect on dopamine receptors



Apomorphine


Notable AEs



  • Injection site reactions, drowsiness, nausea or vomiting, dizziness, postural hypotension, hallucinations, edema. Less common hypersexuality or erections



Apomorphine


Life-Threatening or Dangerous AEs



  • May cause somnolence or sudden onset sleep. Severe orthostatic hypotension and nausea/vomiting, even when compared to other PD treatments



Apomorphine


Weight Gain



  • Unusual



Apomorphine


Sedation



  • Common



Apomorphine


What to Do About AEs



  • Orthostatic hypotension: the first dose should be given in a monitored setting (such as a physician’s office). Check supine and standing blood pressure predose and 20, 40, and 60 minutes after injection. If there is no clinical improvement and no AEs, a dose of 4 mg can be given, no earlier than 2 hours after the initial dose

Feb 16, 2017 | Posted by in PHARMACY | Comments Off on apomorphine

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