Antibodies Discussed

Antibody Name/Symbol

Antibody Description

Clones/Alternative Names

α-1-antichromotrypsin

alpha 1 antichromotrypsin

A1ACT

α-1-antitrypsin

alpha 1 antitrypsin

A1AT

α-amylase

alpha amylase

A-amylase

α-fetoprotein

alpha 1 fetoprotein

AFP, Z5A06, Clone C3

β-catenin

beta catenin; involved in regulation of cell adhesion and in signal transduction through Wnt pathway

B-catenin, CLONE 14, E-5, RB-9035Po, 17C2, 5H10

β-catenin cytoplasm

B-caten-cyt

β-tubulin

beta tubulin

β-tubulin, TUJ1

κ light chain

kappa light chain

KAPPA

λ light chain

lambda light chain

LAMBDA

12C3

early malignant change in ovary, non-commercial

34βE12

cytokeratin -high molecular weight (34bE12- CK 1, 5, 10, 14)

MA-903, CK903

ACTH

adrenocorticotropic hormone

Actin-HHF-35

actin, muscle (HHF35)

MSA, HHF-35

Actin-SM

actin, smooth muscle

SMA, ASM-1, CGA7, 1A4, HUC1-1

AE1/AE3

AE1/AE3; mixture of 2 anticytokeratin clones that detect a variety of both high-and low- molecular weight cytokeratins

AFP

Alpha 1 fetoprotein

α-fetoprotein, Z5A06, Clone C3

ALK

anaplastic lymphoma kinase 1

ALK1, 5A4, ALKC

Amylase

Androgen receptor

Dihydrotestosterone receptor; nuclear receptor subfamily 3, group C, member 4

AR441, F39.4.1, AR-N20, AR27

APC

adenomatous polyposis coliprotein

B72.3

tumor-associated glycoprotein 72

TAG72, CC49, TAG-72, BRST-3

BCL-2

B-cell lymphoma 2; suppresses apoptosis in a variety of cell systems

ONCL2, BCL2/100/D5, 124, 124.3

BCL-6

B-cell CLL /lymphoma 6

LN22, GI191E/A8, N-3, PG-B6P, P1F6, 3FR-1

BCL-10

B-cell CLL/lymphoma 10

151, 331.3

BER-EP4

epithelial cell adhesion molecule

AUA1, VU-1D9, EPCAM, C10, HEA125

Brachyury

crucial regulator of notochordal development and biomarker for chordomas

BRST-2

gross cystic fluid protein 15

GCDFP-15, 23A3, D6, AB-1, SABP, GPIP4, Gp17

CA125

Mucin 16

OV185:1, OC125, MUC16

Calcitonin

polypeptide hormone produced by parafollicular cells (C cells) of the thyroid

CALBINDIN28

Calponin

thin filament-associated protein that is implicated in regulation and modulation of smooth muscle contraction

N3, 26A11, CALP, CNN1, SMCC, Sm Calp

Calretinin

29 kDa calcium binding protein that is expressed in central and peripheral nervous system and in many normal and pathological tissues

DAK-CALRET, 5A5, CAL 3F5, DC8, AB149

CAM5.2

cytokeratin 8/18 (CAM5.2)

5D3, Zym5.2, 5D3, CAM 5.2, KER 10.11, NCL-5D3

CD1a

T-cell surface glycoprotein

JPM30, CD1A, O10, NA1/34

CD2

T-cell surface antigen, LFA2

271, MT910, AB75, LFA-2

CD3

T-cell receptor

F7238, A0452, CD3-P, CD3-M, SP7, PS1

CD4

T-cell surface glycoprotein L3T4

IF6, 1290, 4B12, CD4

CD5

T-cell surface glycoprotein Leu1, T1

NCL-CD5 4C7 54/B4 54/F6

CD8

T-cell coreceptor antigen, Leu2, T-cytotoxic cells

M7103, C8/144, C8/144B

CD10

neutral endopeptidase

CALLA, neprilysin, neutral endopeptidase, NEP

CD11c

integrin alpha X chain protein

LEU-M5

CD15

reacts with Reed-Sternberg cells of Hodgkin disease and with granulocytes

VIM-2,3C4, LEU-M1, TU9, VIM-D5, MY1, CBD1, MMA, 3CD1, C3D1, Lewis x, SSEA-1

CD20

membrane spanning 4 domains of B-lymphocytes

FB1, B1, L26, MS4A1

CD21

CR2, complement component receptor 2, Epstein-Barr virus receptor

IF8

CD23

Fc ε RII, low-affinity IgE receptor, IGEBF

1B12, MHM6BU38

CD24

sialic acid epitope of B lymphocytes

BA-1

CD30

tumor necrosis factor receptor SF8

BER-H2, KI-1, TNFRSF8

CD31

PECAM-1, platelet endothelial cell adhesion molecule

JC/70, JC/70A, PECAM-1

CD34

hematopoietic progenitor cell antigen

MY10, IOM34, QBEND10, 8G12, 1309, HPCA-1, HPCA, NU-4A1, TUK4, clone 581, BI-3c5

CD35

erythrocyte complement receptor 1, CR1, immune adherence receptor, C3b/C4b receptor

CR1, BER-MAC-DRC, TO5, CD35, E11

CD38

acute lymphoblastic leukemia cell antigen, T 10

SPC32, VS38, T10

CD43

Major sialoglycoprotein on surface of human T-lymphocytes, monocytes, granulocytes, and some B-lymphocytes

LEU-22, DF-T1, L60, MT1, sialophorin, leukosialin, SPN

CD45

leukocyte common antigen

LCA, PD7/26, 1.22/4.14, T29/33, RP2/18, PD7, 2D1, 2B11+PD7/26

CD45RA

isoform of CD45 expressed by naive T cells

4KB5, MT2, CD45RA, MB1

CD45RB

isoform of CD45 expressed by naive and memory T cells

CD56

NCAM (neutral cellular adhesion molecule)

MAB 735, ERIC-1, 25-KD11, 123C3, 24-MB2, BC56C04, 1B6, 14-MAB735, NCC-LU-243, MOC-1, NCAM

CD57

β-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)

LEU-7, NK1, HNK-1, TB01, B3GAT1

CD68

cytoplasmic granule protein of monocytes, macrophages

PG-M1, KP-1, LN5

CD70

cellular ligand of TNF receptor family member CD27 that is expressed transiently on activated T and B cells

CD79-α

immunoglobulin-associated alpha, MB1

MB-1, 11D10, 11E3, CD79A, HM47/A9, HM57, JCB117

CD99

cell surface glycoprotein for migration, T cell adhesion, MIC2

CD99-MEMB, MIC2, 12E7, HBA71, O13, P30/32MIC2, M3601

CD117

C-kit; tyrosine-protein kinase activity

C-19 (C-KIT), 104D2, 2E4, C-KIT, A4502, H300, CMA-767

CD138

syndecan; a useful marker for plasma cells

B-B4, AM411-10M, MI15

CD163

Macrophage hemoglobin scavenging system

10D6

CD207

type II transmembrane cell surface receptor produced by Langerhans cells

langerin

CDK4

Cyclin dependent kinase 4

DCS-31

CDX-2

caudal-type homeobox transcription factor 2

AMT28, 7C7/D4, CDX-2-88

CEA-M

carcinoembryonic antigen, monoclonal

mCEA, CEA-B18, CEA-D14, CEA-GOLD 1, T84.6, CEA-GOLD 2, CEA 11, CEA-GOLD 3, CEA 27, CEA-GOLD 4, CEA 41, CEA-GOLD 5, T84.1, CEA-M, A5B7, CEJ065, IL-7, T84.66, TF3H8-1, 0062, D14, alpha-7, PARLAM 1, ZC23, CEM010, A115, COL-1, AF4, 12.140.10, 11-7, M773, CEA-M431_31, CEJO65

CEA-P

carcinoembryonic antigen, polyclonal

CGRP

calcitonin gene related peptide

Chromogranin-A

pituitary secretory protein 1

PHE-5, PHE5, E001, DAK-A3

Chromogranin-B

Secretogranin 1

PE-11, SECRETONEUR

CITED-1

melanocyte specific gene 1 antibody, CBP/P300-interacting transactivator 1

J72220K, MSG1

CK1

cytokeratin 1

CK 01, 34BB4

CK4

cytokeratin 4

215B8, 6B10

CK5/6

cytokeratin 5/6, high molecular weight cytokeratins

D5/16 B4

CK7

cytokeratin 7, low molecular weight cytokeratin

K72.7, KS7.18, OVTL 12/30, LDS-68, CK 07

CK8

cytokeratin 8

K8.8, 4.1.18, TS1, C-51, M20

CK10

cytokeratin 10

LHP1, DE-K10, RKSE60

CK10/13

cytokeratin 10/13

DE-K13, A3.3

CK13

cytokeratin 13

KS13.1, KS-1A3, AE8, 2D7

CK14

cytokeratin 14, high molecular weight cytokeratin

LL002

CK17

cytokeratin 17

E3

CK18

cytokeratin 18

M9, DC-10, CY-90, KS18.04

CK19

cytokeratin 19, low molecular weight cytokeratin

BA17, RCK108, LP2K, B170, A53-BA2, KS19.1, 170.2.14

CK20

cytokeratin 20, low molecular weight cytokeratin

KS20.8

CK8/18/CAM5.2

cytokeratin 8/18; simple epithelial-type cytokeratins

5D3, Zym5.2, CAM 5.2, KER 10.11, NCL-5D3, cytokeratin LMW

CK-HMW-NOS

high molecular weight cytokeratin, not otherwise specified

C-KIT

C-kit; tyrosine-protein kinase activity

CD117, C-19 (C-KIT), 104D2, 2E4, C-KIT, A4502, H300, CMA-767

CK-LMW-NOS

low molecular weight cytokeratin, not otherwise specified

CK-PAN

cytokeratin-pan (AE1/AE3/LP34); cocktail of high and low molecular weight cytokeratins

keratin pan, MAK-6, K576, LU-5, KL-1, KC-8, MNF 116, pankeratin, pancytokeratin

Claudin-1

senescence-associated epithelial membrane protein

JAD.8

Clusterin

clusterin, alpha chain specific

41D, E5

CMV

cytomegalovirus

Collagen IV

major constituent of the basement membranes along with laminins, proteoglycans, and enactins

CIV22, COL4A [1-5], collagen α-1(IV) chain

Cyclin-D1

protein with important cell cycle regulatory functions

bcl-1 (cyclin D1) A-12, PRAD1, AM29, DCS-6, SP4, 5D4, D1GM, P2D11F11, CCND1Cyl-1

Desmin

class III intermediate filaments found in muscle cells

M760, DE-R-11, D33, DE5, DE-U-10, ZC18

EBER

Epstein-Barr virus encoded RNA

EBV-LMP

Epstein-Barr virus latent membrane protein

LMP1, CS 1-4

E-cadherin

epithelial calcium dependent adhesion molecule

36B5, ECH-6, ECCD-2, CDH1, 5H9, NCH 38, CLONE 36, 4A2 C7, E9, 67A4, HECD-1, SC-8426

EGFR

v-erb-b1 erythroblastic leukemia viral gene,epidermal growth factor receptor

2-18C9, EGFR1, EGFR PHRMDX, NCL-R1, H11, C-ERBB-1, E30, EGFR, EGFR.113, 31G7, 3C6

EMA

epithelial membrane antigen

GP1.4, 214D4, MC5, E29

EpCam/BER-EP4/CD326

epithelial cell adhesion molecule

AUA1, VU-1D9, EPCAM, C10, HEA125, BER-EP4

ER

estrogen receptor protein

1D5, 6F11, SP1, 15D, H222, TE111, ERP, ER1D5, NCLER611, NCL-ER-LH2, PGP-1A6

ERP-β

estrogen receptor protein beta

ER-BETA, 14C8, 57/3, PPG5/10

Fascin

marker for Reed-Sternberg cells of Hodgkin disease

55K2

FLI-1

Friend leukemia virus integration 1

GI146-222, SC356

FVIIIRAg

factor VIII-related antigen

F8/86, von Willebrand factor

FXIIIA

factor-XIIIA (fibrin stabilizing factor)

Galectin-3

NCL-GAL3, B2C10, 9C4

GCDFP-15

gross cystic fluid protein 15

23A3, BRST-2, D6, SABP, GPIP4, Gp17

GFAP

glial fibrillary acidic protein

6F2, M761, GA-51, GFAP, GFP-8A

GH

growth hormone

HGH, hGH

GLUT1-cytoplasm

glucose transporter 1-cytoplasmic

GLUT1-CYT

HAM56

Fc receptor for IgG antibodies, high affinity

CD64

HBME-1

mesothelioma antibody

HER2

v-erb-b2 erythroblastic leukemia viral gene protein, human epidermal growth factor receptor 2

Her2/neu, NEU, Her2, NCL-CBE1, 10A7, 9G6.10, SP3, 4B5, P185, 9G6.20, A0485, C-ERBB-2, CB11, ERBB-2, 3B5, TAB250, HERCEPTEST, E2-4001, HER-2_NEU

HHV8

human herpes virus 8

13B10, LNA-1

HMB-45

monoclonal antibody that reacts against an antigen present in melanocytic tumors

HMFG

human milk fat globule 1

HMFG-2

HMGA2

high mobility group chromatin protein A2

HMGI-C

HPP

human pancreatic peptide

HPV

human papilloma virus

HPV 16

human papilloma virus 16

IgA

immunoglobin A

IGF-2

insulin growth factor-like 2

W2-H1

IgG

immunoglobulin G

IGG

IgM

immunoglobin M

IL-15

interleukin 15

IMP3

insulin-like growth factor II MRNA-binding protein 3

L523S

Inhibin-α

produced by ovarian granulosa cells; inhibits production or secretion of pituitary gonadotropins, a sensitive marker for majority of sex cord-stromal tumors

Keratin-Pan

cytokeratin-pan (AE1/AE3/LP34); cocktail of high and low molecular weight cytokeratins

keratin pan, MAK-6, K576, LU-5, KL-1, KC-8, MNF 116, pankeratin, pancytokeratin

KI-67

marker of cell proliferation

MMI, KI88, IVAK-2, MIB1

Laminin

major protein in basal lamina

LAMININ-4C7, 4C12.8, LAM-89

Langerin

CD207 molecule

CD207

LCA

leukocyte common antigen

PD7/26, 1.22/4.14, T29/33, CD45RB, RP2/18, CD45, PD7, 2D1, 2B11+PD7/26

LF

lactoferrin

LH

Luteinizing hormone

beta-LH

LMP1

Epstein-Barr virus latent membrane protein

EBV-LMP, CS 1-4

Lysozyme

1,4-beta N-acetylmuramidase C

Lyz, Lzm, Ec3.2.1.17

MAC387

macrophage antibody

MBP

major basic protein

mCEA

carcinoembryonic antigen, monoclonal

CEA-M, CEA-B18, CEA-D14, CEA-GOLD 1, T84.6, CEA-GOLD 2, CEA 11, CEA-GOLD 3, CEA 27, CEA-GOLD 4, CEA 41, CEA-GOLD 5, T84.1, CEA-M, A5B7, CEJ065, IL-7, T84.66, TF3H8-1, 0062, D14, alpha-7, PARLAM 1, ZC23, CEM010, A115, COL-1, AF4, 12.140.10, 11-7, M773, CEA-M43_31, CEJO65

Mcl-1

myeloid cell leukemia

38G3, MCL-1, S-19

MCM2

Microsome maintenance protein 2

MDM2

murine double minute oncogene (mdm2)

HDM2, IF2, 2A10, 1B10, SMP14, MDM-2

Melan-A

melanoma antigen recognized by T cells 1 (MART-1); protein found on melanocytes; melanocyte differentiation antigen

M2-7C10, CK-MM

Melan-A103

clone of Melan-A

A103

MIB1

KI-67 (MIB1); marker of cell proliferation

MMI, KI88, IVAK-2, MIB1

MIC2

cell surface glycoprotein for migration, T cell adhesion, MIC2

CD99, CD99-MEMB, MIC2, 12E7, HBA71, O13, P30/32MIC2, M3601

MITF

Microphthalmia-associated transcription factor

34CA5, D5, C5+D5

MK

neurite growth promoting factor 2

MIDKINE, MK1

MSA

muscle-specific actin

ACTIN-SM, ASM-1, CGA7, 1A4, HUC1-1

MSG1

melanocyte specific gene 1 antibody

CITED-1, J72220K

MSH2

mutS homolog 2

FE11

MT

metallothionein

CLONE E9

MUC1

epithelial membrane antigen

LICR-LON-M8, BC3, DF3, VU3D1, MUSEII, RD-1, MA695, MA552, PS2P446, 115D8

MUC2

mucin 1, intestinal

CCP58, MUC2-P, M53, MRP, LUM2-3, LDQ10

MYOD1

myogenic differentiation 1

5.8A, 5.2F

Myogenin

myogenic factor 4; class C basic helix-loop-helix protein 3

F5D, MYF3, MYF4, LO26, BHLHc3, cb553, MYF4, MYOG

Myoglobin

Iron and oxygen-binding protein found in muscle tissue

MG-1

Myosin

Motor proteins responsible for actin-based motility in striated and smooth muscle cels

N3

calponin

26A11, CALP

NFP

neurofilament H/M phosphorylated protein

TPNFP-1A3, SMI31, SMI33, NFP, SMI32, TA-51, 2F11

NGFR

nerve growth factor receptor

NSE

neuron specific enolase

BSS/H14

p14

cyclin dependent kinase 4 inhibitor A

P14_ARF

p16

cyclin dependent kinase 4 inhibitor 2A

P16_INK4A, E6H4, sc1661, JC8, ZJ11, P16, G175-405, F-12, DCS-50, 6H12, 16P07, 16P04

p21

Cyclin Dependent Kinase Inhibitor 1A

WAF1, DCS-60.2, EA10, 6B6, 4D10, SX118, P21, P21_WAF1, WAFT

p27

Cyclin Dependent Kinase Inhibitor 1B

P27_KIP1, 57, 1B4, DCS-72.F6, SX53G8, P27, K25020, DCS72, KIP-1

p53

p53 tumor suppressor gene protein

DO7, 21N, BP53-12-1, AB6, CM1, PAB1801, DO1, BP53-11, PAB240, RSP53, MU195, P53

p63

tumor protein p63

H-137, 7JUL

p73

tumor protein p73

AB7824

p80

anaplastic lymphoma kinase-1

KU

Parafibromin

tumor suppressor that is associated with hyperparathyroidism-jaw tumor syndrome

2H1

pax-2

paired box gene 2

Z-RX2, PAX-2

pax-8

paired box gene 8

PAX-8

P-cadherin

placental dependent adhesion protein

56, clone 56

PCNA

proliferating cell nuclear antigen

19 A2, PC10

PDGF-B

platelet derived growth factor B

PGP9.5

protein gene product 9.5

13C4

PLAP

placental alkaline phosphatase

228M, 8A9, 88B

PNA

peanut agglutinin

Podoplanin

marker for reactive follicular dendritic cells and follicular dendritic cell sarcomas

D2-40, M2A

PR

progesterone receptor protein

10A9, PGR-1A6, KD68, PGR-ICA, PRP-P, PRP, PRI, 1A6, 1AR, HPRA3, PGR-636, 636, PR88, NCL-PGR

PRL

prolactin

PSA

prostate specific antigen

PSA-M, PSA, ER-PR8, PSA-P, F5

PTEN

phosphatase and tensin homolog

PN37

PTH

parathyroid hormone

Rb

retinoblastoma associated protein

3C8, 3H9, PRB1, G3-245, RB1, RB-WL 1, RB-1, 1F8, RB

RCC

renal cell carcinoma

66.4C2, PN-15, RCC, RCC MA

ret

Multiple endocrine neoplasia and medullary thyroid carcinoma 1

3F8

S100

Low molecular weight protein normally present in cells derived from neural crest (Schwann cells, melanocytes, and glial cells), chondrocytes, adipocytes, myoepithelial cells, macrophages, Langerhans cells, dendritic cells, and keratinocytes

S-100, A6, 15E2E2, Z311, 4C4.9

S100-A4

S100 calcium binding protein A4

S100-A9

S100 calcium binding protein A9

MRP14

SCC

squamous cell carcinoma-related antigen

F2H7C

Serotonin

5-hydroxytryptamine (5-HT), a monoamine neurotransmitter

5-HT, 5HT-H209

SMHC

myosin heavy chain smooth muscle

ID8, SM_MYOSIN_H, HSM-V, SMMS-1

SNF5

member of SWI/SNF chromatin remodeling complex

BAF47/SNF5, INI1

Somatostatin

somatotropin release-inhibiting factor

Synaptophysin

major synaptic vesicle protein p38 antibody

SVP38, SY38, SNP-88, SYP, SYPH, Sypl, Syn p38

SYT

SYT homolog 1

Tag72

tumor-associated glycoprotein-72

CC49, B72.3, BRST-3

TCR

T-cell antigen receptor

T_CELL_AG_R, BETA-F1, 8A3, BF1

TdT

terminal deoxynucleotidyl transferase

SEN 28

Tenascin

Extracellular matrix glycoprotein

DB7, TN2

TF

Thomsen-Friedrenreich blood group antigen

HB-T1, TF ANTIGEN

Thyroglobulin

dimetric protein specific to thyroid gland

DAK-TG6

TIA

T-cell intracellular antigen 1

NS/1-AG4, 2G9, TIA-1

TLE1

transducer-like enhancer 1

TNF-α

gamma catenin

G-catenin, TNF alpha, alpha alpha

TPO

thyroid peroxidase

THYROPEROX

TSH

thyroid stimulating hormone

beta-TSH

TTF-1

transcription termination factor

8G7G3/1, SPT-24, SC-13040

Tyrosinase

Catalyzes production of melanin

NCL-TYROS, T311

ULEX-1

Ulex europaeus agglutinin-1

ULEX, UEA1

VCA

Epstein Barr virus- viral capsid antigen

EBV-VCA

Villin

protein binding the actin filaments of microvillar cores

1D2C3

Vimentin

major subunit protein of intermediate filaments of mesenchymal cells

43BE8, 3B4, V10, V9, VIM-B34, VIM

Von Willebrand factor

factor VIII-related antigen

FVIIIRAg, F*/86

WT1

Wilms tumor gene-1

6F-H2, C-19