Angioleiomyoma
Cyril Fisher, MD, DSc, FRCPath
Key Facts
Terminology
Benign neoplasm composed of blood vessels and smooth muscle cells in varying proportions
Clinical Issues
Most common between 40-60 years
Mostly in subcutis; can be painful
Macroscopic Features
Well-defined nodule
Microscopic Pathology
Smooth muscle bundles
Arranged around thick-walled vessels
Fascicles radiate from vessel wall
Rarely nuclear atypia, no mitoses or necrosis
Usually have narrow lumina
Top Differential Diagnoses
Myopericytoma
Leiomyoma
 Angioleiomyoma is circumscribed and can be “shelled out.” A thin rim of subcutaneous adipose tissue  is seen enclosing the excision specimen. This pattern is sometimes termed the solid variant. |
 The cavernous type of angioleiomyoma has thin-walled dilated vascular channels arranged in small clusters  within a stroma composed of smooth muscle fibers that form branching fascicles  . |
TERMINOLOGY
Synonyms
Angiomyoma
Vascular leiomyoma
Definitions
Benign neoplasm composed of blood vessels and smooth muscle cells in varying proportions
CLINICAL ISSUES
Epidemiology
Incidence
About 25% of superficial leiomyomas
Age
Most common between 40-60 years
Gender
Females > males
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