The ability of cannabis medicines to encourage appetite is part of popular culture: the “munchies.” Cachexia was once the least controversial medicinal property of cannabis, but not always the best understood. Some forms of cachexia, especially ones associated with advanced cancer, may not respond to cannabis. The 2006 clinical study of cannabis with advanced cancer patients, conducted by the Cannabis in Cachexia Study Group, was discontinued when cannabis showed little advantage over the placebo, and produced more side effects. While this was only one study, it has been widely cited as evidence that cannabis is of little use in cancer cachexia, though this remains disputed.29 Cachexia, also known as wasting syndrome, results in emaciation, weakness, and fatigue. It is currently characterized by skeletal muscle loss with or without the loss of fat tissue.31
CACHEXIA AND APPETITE DISORDERS
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