Amyloid Tumor
Key Facts
Terminology
Synonym
Amyloidoma
Definition
Pulmonary mass composed of amyloid without evidence of systemic disease
Etiology/Pathogenesis
Specific cause to account for presence of amyloid in lung without systemic disease unknown; speculated to be related to
Light chain immunoglobulin
Plasma cells
Associated conditions
Waldenström macroglobulinemia
Systemic amyloidosis
Multiple myeloma
Familial neuropathy
Niemann-Pick disease
Gaucher disease
Clinical Issues
Rare occurrence
Predominantly in adults
Laboratory tests
Potassium permanganate oxidation technique appears to separate amyloid type AA from other types
Top Differential Diagnoses
Hyalinizing granuloma of lung
Intrapulmonary solitary fibrous tumor
 Low-power view of a pulmonary amyloid tumor shows dense amorphous material replacing normal lung parenchyma  . Adjacent lung parenchyma appears to be within normal limits  . |
 High-power view of a pulmonary amyloid tumor shows dense amorphous acellular material  with only focal areas of inflammatory reaction  . These features are classic for an amyloid tumor. |
TERMINOLOGY
Synonyms
Amyloidoma
Definitions
Pulmonary mass composed of amyloid without evidence of systemic disease
ETIOLOGY/PATHOGENESIS
Etiology
Specific cause to account for presence of amyloid in lung without systemic disease is unknown
Speculated to be related to
Light chain immunoglobulin
Plasma cells
Associated Conditions
Waldenström macroglobulinemia
Systemic amyloidosis
Multiple myeloma
Familial neuropathy
Niemann-Pick disease
Gaucher disease
CLINICAL ISSUES
Epidemiology
Incidence
Rare occurrence
Age
Predominantly in adults
Gender
No gender predilection
Ethnicity
No apparent ethnic predilection
Presentation
Cough
Chest pain
Dyspnea
Sjögren syndrome
Laboratory Tests
Potassium permanganate oxidation technique appears to separate amyloid type AA from other forms of amyloid
Treatment
Surgical approaches
Surgical resection of tumor mass by wedge resection or lobectomy
Prognosis
It will depend on any possible associated condition
MACROSCOPIC FEATURES
General Features
Single or multiple pulmonary nodules
Soft and well circumscribed
Size can range from 1 cm to > 10 cm in diameter
Light tan in color
MICROSCOPIC PATHOLOGY
Histologic Features
There are essentially 2 patterns in which the lung may be affected
Interstitial and diffuse pattern
Nodular
Acellular amorphous eosinophilic material destroying lung parenchyma
Subtle inflammatory infiltrate predominantly in periphery
Numerous multinucleated giant cells
Focal areas of ossification may be present
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