Aminoglycoside-Induced Oxidative Stress: Pathways and Protection




Davis JM, Elfenbein J, Schum R, Bentler RA (1986) Effects of mild and moderate hearing impairments on language, educational, and psychosocial behavior of children. J Speech Hear Disord 51(1):53–62PubMed


de Groot JC, Meeuwsen F, Ruizendaal WE, Veldman JE (1990) Ultrastructural localization of gentamicin in the cochlea. Hear Res 50(1–2):35–42PubMed


Dehne N, Rauen U, de Groot H, Lautermann J (2002) Involvement of the mitochondrial permeability transition in gentamicin ototoxicity. Hear Res 169(1–2):47–55PubMed


Ding D, Stracher A, Salvi RJ (2002) Leupeptin protects cochlear and vestibular hair cells from gentamicin ototoxicity. Hear Res 164(1–2):115–126PubMed


Duggal P, Sarkar M (2007) Audiologic monitoring of multi-drug resistant tuberculosis patients on aminoglycoside treatment with long term follow-up. BMC Ear Nose Throat Disord 7:5. doi:10.​1186/​1472-6815-7-5 PubMedCentralPubMed


Dulon D, Aran JM, Zajic G, Schacht J (1986) Comparative uptake of gentamicin, netilmicin, and amikacin in the guinea pig cochlea and vestibule. Antimicrob Agents Chemother 30(1):96–100PubMedCentralPubMed


Dulon D, Zajic G, Aran JM, Schacht J (1989) Aminoglycoside antibiotics impair calcium entry but not viability and motility in isolated cochlear outer hair cells. J Neurosci Res 24(2):338–346. doi:10.​1002/​jnr.​490240226 PubMed


Dulon D, Hiel H, Aurousseau C, Erre JP, Aran JM (1993) Pharmacokinetics of gentamicin in the sensory hair cells of the organ of Corti: rapid uptake and long term persistence. C R Acad Sci III 316(7):682–687PubMed


Elfenbein JL, Hardin-Jones MA, Davis JM (1994) Oral communication skills of children who are hard of hearing. J Speech Hear Res 37(1):216–226PubMed


Eshraghi AA, Hoosien G, Ramsay S et al (2010) Inhibition of the JNK signal cascade conserves hearing against electrode insertion trauma-induced loss. Cochlear Implants Int 11(suppl 1):104–109. doi:10.​1179/​146701010X126711​77544104 PubMed


Estivill X, Govea N, Barcelo E et al (1998) Familial progressive sensorineural deafness is mainly due to the mtDNA A1555G mutation and is enhanced by treatment of aminoglycosides. Am J Hum Genet 62:27–35PubMedCentralPubMed


Fausti SA, Henry JA, Schaffer HI, Olson DJ, Frey RH, McDonald WJ (1992) High-frequency audiometric monitoring for early detection of aminoglycoside ototoxicity. J Infect Dis 165(6):1026–1032PubMed


Fee WE Jr (1980) Aminoglycoside ototoxicity in the human. Laryngoscope 90(10 pt 2 suppl 24):1–19PubMed


Feldman L, Efrati S, Eviatar E et al (2007) Gentamicin-induced ototoxicity in hemodialysis patients is ameliorated by N-acetylcysteine. Kidney Int 72(3):359–363. doi:10.​1038/​sj.​ki.​5002295 PubMed


Fetoni AR, Sergi B, Ferraresi A, Paludetti G, Troiani D (2004) alpha-Tocopherol protective effects on gentamicin ototoxicity: an experimental study. Int J Audiol 43(3):166–171PubMed


Fischel-Ghodsian N (2005) Genetic factors in aminoglycoside toxicity. Pharmacogenomics 6(1):27–36. doi:10.​1517/​14622416.​6.​1.​27 PubMed


Forge A, Fradis M (1985) Structural abnormalities in the stria vascularis following chronic gentamicin treatment. Hear Res 20(3):233–244PubMed


Forge A, Schacht J (2000) Aminoglycoside antibiotics. Audiol Neurootol 5(1):3–22PubMed


Forge A, Li L, Corwin JT, Nevill G (1993) Ultrastructural evidence for hair cell regeneration in the mammalian inner ear. Science 259(5101):1616–1619PubMed


Forge A, Li L, Nevill G (1998) Hair cell recovery in the vestibular sensory epithelia of mature guinea pigs. J Comp Neurol 397(1):69–88PubMed


Garetz SL, Altschuler RA, Schacht J (1994) Attenuation of gentamicin ototoxicity by glutathione in the guinea pig in vivo. Hear Res 77(1–2):81–87PubMed


Gatell JM, Ferran F, Araujo V et al (1987) Univariate and multivariate analyses of risk factors predisposing to auditory toxicity in patients receiving aminoglycosides. Antimicrob Agents Chemother 31(9):1383–1387PubMedCentralPubMed


Govaerts PJ, Claes J, van de Heyning PH, Jorens PG, Marquet J, De Broe ME (1990) Aminoglycoside-induced ototoxicity. Toxicol Lett 52(3):227–251PubMed


Grohskopf LA, Huskins WC, Sinkowitz-Cochran RL et al (2005) Use of antimicrobial agents in United States neonatal and pediatric intensive care patients. Pediatr Infect Dis J 24(9):766–773PubMed


Hainrichson M, Nudelman I, Baasov T (2008) Designer aminoglycosides: the race to develop improved antibiotics and compounds for the treatment of human genetic diseases. Org Biomol Chem 6(2):227–239. doi:10.​1039/​b712690p PubMed


Harvey SC, Li X, Skolnick P, Kirst HA (2000) The antibacterial and NMDA receptor activating properties of aminoglycosides are dissociable. Eur J Pharmacol 387(1):1–7PubMed


Hashino E, Shero M, Salvi RJ (1997) Lysosomal targeting and accumulation of aminoglycoside antibiotics in sensory hair cells. Brain Res 777(1–2):75–85PubMed


Hawkins E Jr (1973) Ototoxic mechanisms. A working hypothesis. Audiology 12(5):383–393PubMed


Hawkins JE (1976) Drug ototoxicity. In: Keidel WD, Neff WD (eds) Handbook of sensory physiology, vol 5. Springer, Berlin, pp 707–748


Henley CM III, Schacht J (1988) Pharmacokinetics of aminoglycoside antibiotics in blood, inner-ear fluids and tissues and their relationship to ototoxicity. Audiology 27(3):137–146PubMed


Hennig S, McKay K, Vidmar S, O’Brien K, Stacey S, Cheney J, Wainwright CE (2014) Safety of inhaled (TOBI) and intravenous tobramycin in young children with cystic fibrosis. J Cyst Fibros 13:428–434PubMed


Hiel H, Bennani H, Erre JP, Aurousseau C, Aran JM (1992) Kinetics of gentamicin in cochlear hair cells after chronic treatment. Acta Otolaryngol 112(2):272–277PubMed


Hinojosa R, Lerner SA (1987) Cochlear neural degeneration without hair cell loss in two patients with aminoglycoside ototoxicity. J Infect Dis 156(3):449–455PubMed


Hinshaw HC, Feldman DVM (1945) Streptomycin in treatment of clinical tuberculosis: a preliminary report. Proc Staff Meet Mayo Clin 20:313–318


Hirose K, Hockenbery DM, Rubel EW (1997) Reactive oxygen species in chick hair cells after gentamicin exposure in vitro. Hear Res 104(1–2):1–14PubMed


Horvath P, Barrangou R (2010) CRISPR/Cas, the immune system of bacteria and archaea. Science 327(5962):167–170. doi:10.​1126/​science.​1179555 PubMed


Houghton JL, Green KD, Chen W, Garneau-Tsodikova S (2010) The future of aminoglycosides: the end or renaissance? Chembiochem 11(7):880–902. doi:10.​1002/​cbic.​200900779 PubMed


Imamura S, Adams JC (2003) Distribution of gentamicin in the guinea pig inner ear after local or systemic application. J Assoc Res Otolaryngol 4(2):176–195. doi:10.​1007/​s10162-002-2036-8 PubMedCentralPubMed


Jiang H, Sha SH, Schacht J (2005) NF-kappaB pathway protects cochlear hair cells from aminoglycoside-induced ototoxicity. J Neurosci Res 79(5):644–651. doi:10.​1002/​jnr.​20392 PubMed


Jiang H, Sha SH, Forge A, Schacht J (2006a) Caspase-independent pathways of hair cell death induced by kanamycin in vivo. Cell Death Differ 13(1):20–30. doi:10.​1038/​sj.​cdd.​4401706 PubMedCentralPubMed


Jiang H, Sha SH, Schacht J (2006b) Kanamycin alters cytoplasmic and nuclear phosphoinositide signaling in the organ of Corti in vivo. J Neurochem 99(1):269–276. doi:10.​1111/​j.​1471-4159.​2006.​04117.​x PubMed


Jiang H, Sha SH, Schacht J (2006c) Rac/Rho pathway regulates actin depolymerization induced by aminoglycoside antibiotics. J Neurosci Res 83(8):1544–1551. doi:10.​1002/​jnr.​20833 PubMedCentralPubMed


Kalghatgi S, Spina CS, Costello JC et al (2013) Bactericidal antibiotics induce mitochondrial dysfunction and oxidative damage in mammalian cells. Sci Transl Med 5(192):192ra85. doi:10.​1126/​scitranslmed.​3006055 PubMedCentralPubMed

Oct 29, 2016 | Posted by in PATHOLOGY & LABORATORY MEDICINE | Comments Off on Aminoglycoside-Induced Oxidative Stress: Pathways and Protection

Full access? Get Clinical Tree

Get Clinical Tree app for offline access