Alveolar Adenoma

Alveolar Adenoma
Pulmonary alveolar adenoma shows characteristic cystic areas alternating with more solid areas. The low power mimics a vascular neoplasm.
Alveolar adenoma shows a more solid proliferation in which the cells appear to have clear cytoplasm. Note the absence of cellular atypia or mitotic activity.
TERMINOLOGY
Definitions
  • Benign intraparenchymal lung tumor
ETIOLOGY/PATHOGENESIS
Etiology
  • Although the etiology of this tumor is not completely understood, it may originate from pneumocytes
CLINICAL ISSUES
Epidemiology
  • Incidence
    • Rare tumor
  • Age
    • Generally in adults
  • Gender
    • No gender predilection
  • Ethnicity
    • No ethnic predilection
Site
  • Intrapulmonary mass
Presentation
  • Cough
  • Chest pain
  • Asymptomatic
Treatment
  • Surgical approaches
    • Lobectomy
    • Wedge resection
Prognosis
  • Excellent
IMAGE FINDINGS
General Features
  • Location
    • Solitary pulmonary mass
MACROSCOPIC FEATURES
General Features
  • Tumors may be cystic and hemorrhagic
Size
  • Tumors may vary from 1-3 cm in diameter
MICROSCOPIC PATHOLOGY
Histologic Features
  • Well circumscribed
  • Generally cystic appearance
  • Dilated spaces of different sizes
  • Clear acellular material within cystic areas
  • Dilated spaces lined by medium-sized cells with hobnail appearance
  • Focal areas of glandular appearance
  • Alternating solid areas
  • Mild inflammatory component composed of lymphocytes and plasma cells
  • Absence of mitotic activity
  • Absence of necrosis
ANCILLARY TESTS
Histochemistry
  • PAS-diastase
    • Reactivity: Positive
Jul 9, 2016 | Posted by in PATHOLOGY & LABORATORY MEDICINE | Comments Off on Alveolar Adenoma

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