Alveolar Adenoma
Key Facts
Terminology
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Benign intraparenchymal lung tumor
Etiology/Pathogenesis
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Although the etiology of this tumor is not completely understood, it may originate from pneumocytes
Clinical Issues
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General features
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Unusual occurrence
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Generally in adults
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Solitary pulmonary lesion
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Cough
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Chest pain
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-
Treatment
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Lobectomy
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Wedge resection
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Prognosis
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Excellent
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Microscopic Pathology
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Well circumscribed
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Generally cystic appearance
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Dilated spaces of different sizes
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Clear acellular material within cystic areas
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PAS-positive material
Top Differential Diagnoses
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Adenocarcinoma
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Bronchioloalveolar carcinoma
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Lymphangioma
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Glomus tumor
TERMINOLOGY
Definitions
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Benign intraparenchymal lung tumor
ETIOLOGY/PATHOGENESIS
Etiology
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Although the etiology of this tumor is not completely understood, it may originate from pneumocytes
CLINICAL ISSUES
Epidemiology
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Incidence
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Rare tumor
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Age
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Generally in adults
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Gender
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No gender predilection
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Ethnicity
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No ethnic predilection
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Site
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Intrapulmonary mass
Presentation
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Cough
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Chest pain
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Asymptomatic
Treatment
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Surgical approaches
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Lobectomy
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Wedge resection
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Prognosis
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Excellent
IMAGE FINDINGS
General Features
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Location
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Solitary pulmonary mass
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MACROSCOPIC FEATURES
General Features
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Tumors may be cystic and hemorrhagic
Size
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Tumors may vary from 1-3 cm in diameter
MICROSCOPIC PATHOLOGY
Histologic Features
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Well circumscribed
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Generally cystic appearance
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Dilated spaces of different sizes
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Clear acellular material within cystic areas
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Dilated spaces lined by medium-sized cells with hobnail appearance
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Focal areas of glandular appearance
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Alternating solid areas
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Mild inflammatory component composed of lymphocytes and plasma cells
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Absence of mitotic activity
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Absence of necrosis
ANCILLARY TESTS
Histochemistry
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PAS-diastase
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Reactivity: Positive
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DIFFERENTIAL DIAGNOSIS

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