Tumor of the Follicular Infundibulum
David Cassarino, MD, PhD
Key Facts
Terminology
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Tumor of the follicular infundibulum (TFI)
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Basal cell hamartoma with follicular differentiation
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Bland, superficial, plate-like adnexal proliferation with multiple epidermal attachments
Etiology/Pathogenesis
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May be sporadic (most cases) or part of Cowden syndrome (multiple, often with tricholemmomas)
Microscopic Pathology
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Multiple connections between lesion and epidermis
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Cells show abundant pale to clear-staining cytoplasm
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Peripheral cells often show palisading
Top Differential Diagnoses
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Basal cell carcinoma
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Inverted follicular keratosis
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Tricholemmoma
TERMINOLOGY
Abbreviations
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Tumor of the follicular infundibulum (TFI)
Synonyms
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Basal cell hamartoma with follicular differentiation
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Mehregan tumor of follicular infundibulum
Definitions
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Benign proliferation of mature adnexal keratinocytes showing a superficial plate-like formation with multiple epidermal attachments
ETIOLOGY/PATHOGENESIS
Unknown
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Most cases are sporadic
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