Trichofolliculoma

Steven D. Billings, MD

Key Facts

Clinical Issues

Usually presents on the face
Benign hamartomatous lesion
Face is most common location

Microscopic Pathology

Cystic tumor that communicates to overlying epidermis
Cystic space filled with keratinous debris and hair shafts
Numerous small, primitive follicles radiate around periphery of the tumor and communicate with central cystic space
May have small attached sebaceous glands
Follicles surrounded by perifollicular stromal sheath

Top Differential Diagnoses

Folliculosebaceous cystic hamartoma
Dilated pore of Winer
Trichoepithelioma

Trichofolliculoma is an invaginated cystic tumor lined by keratinizing squamous epithelium that communicates with the overlying epidermis. The central cystic space is usually filled with keratinous debris.

Radiating around the central cystic space are numerous primitive follicles that connect with the central cystic space. The follicles often have secondary branching