Sinonasal Inflammatory Polyp



Sinonasal Inflammatory Polyp


Bruce M. Wenig, MD










Polypoid mass is seen with intact surface (respiratory) epithelium image and underlying stroma characterized by edema, inflammatory infiltrate, increased vascularity image, and absence of mucoserous glands.






H&E shows edematous stroma with mixed chronic inflammatory cell infiltrate dominated by eosinophils, as well as mature lymphocytes, plasma cells, and neutrophils. A mucoserous gland is present image.


TERMINOLOGY


Definitions



  • Nonneoplastic inflammatory swellings of sinonasal mucosa


ETIOLOGY/PATHOGENESIS


Multifactorial



  • Etiology linked to multiple factors including



    • Allergy (atopy)


    • Infections


    • Cystic fibrosis


    • Diabetes mellitus


    • Aspirin intolerance


    • Familial


CLINICAL ISSUES


Epidemiology



  • Age



    • Occurs in all ages but commonly seen in adults over 20 years old


    • Rarely seen in children less than 5 years old



      • Exception in patients with cystic fibrosis who develop nasal polyps in 1st and 2nd decades of life


  • Gender



    • Equal gender distribution


Site



  • Most arise from lateral nasal wall or ethmoid recess



    • Normal physiologic parameters of lateral nasal cavity mucosa are such that prominent edema readily forms in mucosal lamina propria



      • Makes this site more susceptible to development of polyps


    • May be unilateral or bilateral, single or multiple


  • Not infrequently, involvement of both nasal cavity and paranasal sinuses


Presentation



  • Nasal obstruction, rhinorrhea, and headaches


  • Samter triad



    • Nasal polyps, asthma, and aspirin intolerance


  • Rarely, may be associated with bone erosion, destruction, blindness


Endoscopic Findings



  • Mulberry turbinate



    • Clinical term referring to swollen nasal turbinate tissue


    • Formed as result of edema interspersed among thick vessel walls of normal turbinate vascularity


    • Appearance may clinically suggest pathologic process, such as vascular malformation


Treatment



  • Options, risks, complications



    • Identification and treatment of possible etiologic factor(s) is initial approach in treatment


  • Surgical approaches



    • Polypectomy



      • Medial maxillectomy (Caldwell-Luc procedure) including removal of stalk for antrochoanal polyps


  • Drugs



    • Patients with cystic fibrosis may respond to medical therapy, but surgical resection may be required


Prognosis



  • Approximately 50% of patients will have recurrence following surgery



    • Recurrence rates highest in patients with aspirin intolerance and asthma


  • Development of functional endoscopic sinus surgery contributed to




    • Decreasing morbidity of sinonasal surgery and recurrence of nasal polyposis in patients with cystic fibrosis


    • Improving sinonasal-related symptomatology for asthmatic patients


IMAGE FINDINGS


General Features

Jul 7, 2016 | Posted by in PATHOLOGY & LABORATORY MEDICINE | Comments Off on Sinonasal Inflammatory Polyp

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