Sepsis in the Liver



Sepsis in the Liver


Laura Webb Lamps, MD









Hematoxylin & eosin shows proliferated bile ductules at the periphery of the portal tract that contain dense, inspissated bile image (ductular cholestasis).






Hematoxylin & eosin shows canalicular cholestasis image without significant accompanying inflammation. “Pure” cholestasis is common in infants and children.


TERMINOLOGY


Definitions



  • Spectrum of hepatic injury in patients with sepsis or bacteremia


ETIOLOGY/PATHOGENESIS


Infectious Agents



  • Systemic infection, usually bacterial



    • Most common underlying infectious processes



      • Bacterial pneumonia


      • Intraabdominal suppurative infection


  • Mechanism uncertain



    • Presumably, bacterial endotoxins interfere with normal ductular secretory activity and resorption

Jul 7, 2016 | Posted by in PATHOLOGY & LABORATORY MEDICINE | Comments Off on Sepsis in the Liver
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