Sepsis in the Liver

Sepsis in the Liver

Laura Webb Lamps, MD

Hematoxylin & eosin shows proliferated bile ductules at the periphery of the portal tract that contain dense, inspissated bile image (ductular cholestasis).

Hematoxylin & eosin shows canalicular cholestasis image without significant accompanying inflammation. “Pure” cholestasis is common in infants and children.



  • Spectrum of hepatic injury in patients with sepsis or bacteremia


Infectious Agents

  • Systemic infection, usually bacterial

    • Most common underlying infectious processes

      • Bacterial pneumonia

      • Intraabdominal suppurative infection

  • Mechanism uncertain

    • Presumably, bacterial endotoxins interfere with normal ductular secretory activity and resorption

Jul 7, 2016 | Posted by in PATHOLOGY & LABORATORY MEDICINE | Comments Off on Sepsis in the Liver

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