Sebaceoma (Sebaceous Epithelioma)



Sebaceoma (Sebaceous Epithelioma)


David Cassarino, MD, PhD










Low magnification of a sebaceoma shows a dermal-based basaloid to clear cell neoplasm with peripheral basaloid cells surrounding central collections of clear cells image and sebaceous secretions.






High magnification of a sebaceoma shows a predominantly basaloid population of cells surrounding several large clear cells image with abundant, multivacuolated cytoplasm.


TERMINOLOGY


Synonyms



  • Sebaceous epithelioma (older term, should be discouraged)


Definitions



  • Benign proliferation of mature sebaceous cells associated with a predominant basaloid cell population


ETIOLOGY/PATHOGENESIS


Unknown in Most Cases



  • Some cases are part of Muir-Torre syndrome (MTS)



    • Autosomal dominant disease due to mutations in mismatch repair genes MLH1, MSH2, MSH6


    • Patients present with multiple sebaceous tumors including sebaceous adenomas, sebaceomas, and sebaceous carcinomas


    • Also associated with internal malignancies including gastrointestinal carcinomas (most common), genitourinary, breast, and ovarian tumors


  • Rare cases arise in nevus sebaceous of Jadassohn


CLINICAL ISSUES


Epidemiology



  • Incidence



    • Rare tumors


  • Age



    • Typically occur in adults


Site



  • Often occur on face, but may also present on trunk


Presentation



  • Slow-growing papular to nodular lesion



    • Usually single, but may be multiple, especially in MTS


  • Flesh-colored to yellowish


Treatment



  • Surgical approaches



    • Complete conservative excision is curative


Prognosis



  • Excellent; very low malignant potential



    • Possible transformation to sebaceous carcinoma in longstanding lesions


MACROSCOPIC FEATURES


Size



  • Usually measure between 0.5-3 cm in diameter


MICROSCOPIC PATHOLOGY


Histologic Features

Jul 8, 2016 | Posted by in PATHOLOGY & LABORATORY MEDICINE | Comments Off on Sebaceoma (Sebaceous Epithelioma)
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