Reoperative Parathyroidectomy



Reoperative Parathyroidectomy


Barnard J. A. Palmer

William B. Inabnet III





PATIENT HISTORY AND PHYSICAL FINDINGS



  • A detailed history of the patient’s disease should be performed, focusing on the management to date.


  • Biochemical confirmation of persistent or recurrent hyperparathyroidism is the initial step in management. A 24-hour collection for calcium is recommended.1,2


  • The benefits of reoperation must be weighed against the risks of continued hyperparathyroidism and the surgical complications for each individual patient. Nonsurgical management can be considered if the sequela of continued parathyroid disease is relatively low risk or the risk of operation is high.


  • Surgical history is an essential component of reoperative parathyroid surgery. The surgeon must understand reasons for initial operative failure.3


  • Operative and pathology reports should be carefully reviewed, focusing on the extent of exploration, glands identified and removed, whether confirmed by biopsy, if marked, and if reimplanted.


IMAGING AND OTHER DIAGNOSTIC STUDIES



  • Extensive preoperative planning is key to successful reoperative surgery.


  • Previous operative reports, imaging, and pathology results should be obtained and reviewed to understand the cause of failure.2


  • Localization studies are an essential portion of preoperative planning and should be performed in all reoperative parathyroid patients. Ultrasound, sestamibi, computed tomography (CT) (parathyroid protocol, 4-D) (FIG 1), single-photon emission computed tomography-computed tomography (SPECT/CT), and fluorodeoxyglucose-positron emission tomography (FDG-PET) can be used for localization and to rule out multigland disease. Preoperative location of abnormal glands can significantly alter the operative approach particularly if aberrant glands lie in the mediastinum.


  • Fine needle aspiration (FNA) with measurement of parathyroid hormone (PTH) can confirm parathyroid tissue in questionable lesions or parathyroid adenomatosis identified by ultrasound.


  • Invasive localization studies such as selective venous sampling (FIG 2) or arteriography should be reserved for when noninvasive studies fail to localize pathology.


SURGICAL MANAGEMENT


Preoperative Planning



  • The imaging must be thoroughly reviewed to plan the operative approach.


  • Prior operative notes are reviewed and operative steps clearly determined prior to reexploration.


  • Positively localized lesions lend themselves to focused reexplorations, whereas more extensive exploration is required for multigland or nonlocalized diseases.


  • Preoperative flexible laryngoscopy is recommended prior to reoperative surgery to document vocal cord function and guide the extent of surgery.


  • Frozen section and intraoperative PTH assays are useful adjuncts to confirm parathyroid identification and biochemical cure.






FIG 1 • Parathyroid CT demonstrates a contrastenhancing lesion posterior to the right common carotid artery, posterolateral to the trachea, and lateral to the esophagus, representing a right inferior parathyroid adenoma.







FIG 2 • Selective venous sampling schematic lists PTH levels at different anatomic locations and is consistent with a right midlobe parathyroid adenoma.


Positioning



  • The patient is positioned either supine or in the semi-Fowler position. Both arms are tucked and neck extension is achieved with a shoulder roll (FIG 3).


  • Surgical prep must be wide enough to allow access superiorly to angle of mandible and inferiorly to xiphoid in the instance that sternotomy is necessary.


  • General endotracheal anesthesia permits the use of intraoperative nerve monitoring.






FIG 3 • The patient is placed supine with both arms tucked. A shoulder roll provides additional neck extension, which elevates the trachea anteriorly and superior mediastinal structures cephalad.


Jul 24, 2016 | Posted by in GENERAL SURGERY | Comments Off on Reoperative Parathyroidectomy

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