Renal Lymphomas
Yimin Ge, MD
Jun Zhang, MD, MS
Key Facts
Clinical Issues
-
PRL accounts for 0.7% of all extranodal lymphomas, including Hodgkin and non-Hodgkin lymphomas
-
SRL is 30x more common than PRL
Cytopathology
-
Hypercellular aspirate
-
Dispersed and uniform population of lymphocytes with scant cytoplasm
-
Nuclear atypia varies with lymphoma types
-
Lymphoglandular bodies in background
Top Differential Diagnoses
-
Infection and inflammation
-
Primary or metastatic tumors
Diagnostic Checklist
-
Key to correct diagnosis is to recognize individual atypical lymphocytes and lymphoglandular bodies
-
Specimen should be prioritized for flow cytometry
(A) Diff-Quik-stained fine-needle aspiration of a renal follicular lymphoma shows medium-sized cells with irregular or cleaved nuclei  and lymphoglandular bodies in the background  . (B) Pap-stained small lymphocytic lymphoma shows monotonous population of slightly enlarged lymphocytes with coarse chromatin. (C) Diff-Quik-stained diffuse large B-cell lymphoma demonstrates large lymphocytes with pronounced nuclear irregularity  and pleomorphism. (D) Immunostain for cyclin-D1 shows diffuse nuclear stain in a renal mantle cell lymphoma on cell block. |
CLINICAL ISSUES
Epidemiology
-
Incidence
-
Primary renal lymphoma (PRL) accounts for 1% of all renal lesions and 0.7% of all extranodal lymphomas
-
< 100 cases of PRL were reported, including Hodgkin and non-Hodgkin lymphomas
Stay updated, free articles. Join our Telegram channel
-
Full access? Get Clinical Tree
