Pseudomesotheliomatous Adenocarcinoma



Pseudomesotheliomatous Adenocarcinoma











In this pseudomesotheliomatous adenocarcinoma, note the presence of diffuse pleural thickening image, as well as the presence of distinct intrapulmonary nodules image.






Malignant glands are invading fibroconnective tissue of the pleura. Note the presence of malignant cells, some of them showing intracytoplasmic mucin image.


TERMINOLOGY


Definitions



  • Malignant epithelial neoplasm of lung origin growing along pleural surface


ETIOLOGY/PATHOGENESIS


Environmental Exposure



  • Has been linked to the following



    • Tobacco smoke


    • Asbestos exposure


    • Iron exposure


    • Stone dust exposure


CLINICAL ISSUES


Epidemiology



  • Incidence



    • Tumor of rare occurrence


  • Age



    • Majority of patients are > 50 years old


  • Gender



    • Tumor may be more common in men


Presentation



  • Cough


  • Shortness of breath


  • Chest pain


  • Weight loss


  • Pleural effusion


Treatment



  • Adjuvant therapy



    • Chemotherapy


Prognosis



  • Poor with survival of < 18 months


IMAGE FINDINGS


General Features



  • Tumor mimics radiographic findings of mesothelioma


MACROSCOPIC FEATURES


General Features



  • Thickening of pleura


  • Encasement of lung parenchyma


  • Tumor growth along pulmonary septum


  • Discrete peripheral intrapulmonary tumor


MICROSCOPIC PATHOLOGY

Jul 9, 2016 | Posted by in PATHOLOGY & LABORATORY MEDICINE | Comments Off on Pseudomesotheliomatous Adenocarcinoma
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