Peritonitis is an acute or chronic inflammation of the peritoneum, the membrane that lines the abdominal cavity and covers the visceral organs. Inflammation may extend throughout the peritoneum, or it may be localized as an abscess.

Peritonitis commonly decreases intestinal motility and causes intestinal distention with gas. Mortality is 10%, with death usually resulting from bowel obstruction; the mortality was much higher before the introduction of antibiotics.


Although the GI tract normally contains bacteria, the peritoneum is sterile. In peritonitis, however, bacteria invade the peritoneum. Generally, such infection results from inflammation and perforation of the GI tract, allowing bacterial invasion. Usually, this is a result of appendicitis, diverticulitis, peptic ulcer, ulcerative colitis, volvulus, strangulated obstruction, perforated or ruptured gallbladder, gangrenous gallbladder, abdominal neoplasm, or a penetrating wound.

Peritonitis may also result from chemical inflammation, as in the rupture of a fallopian tube or the bladder, perforation of a gastric ulcer, or release of pancreatic enzymes.

With chemical and bacterial inflammation, accumulated fluids containing protein and electrolytes make the transparent peritoneum opaque, red, inflamed, and edematous. Because the peritoneal cavity is so resistant to contamination, such infection is often localized as an abscess instead of disseminated as a generalized infection.

Signs and symptoms

The key symptom of peritonitis is sudden, severe, and diffuse abdominal pain that tends to intensify and localize in the area of the underlying disorder.

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Jun 16, 2016 | Posted by in GENERAL & FAMILY MEDICINE | Comments Off on Peritonitis

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