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 Figure 5.1.1 This sclerosed intraductal papilloma contains a central sclerotic nodule which deforms the adjacent epithelium. |
 Figure 5.1.2 Central sclerosis entraps the epithelium and deforms areas of hyperplasia peripherally in this intraductal papilloma. |
 Figure 5.1.3 The entrapped glandular structures within this sclerosed papilloma generally maintain a parallel relationship. The peripheral epithelium shows hyperplasia without atypia. |
 Figure 5.1.7 A fibroadenoma showing sharp circumscription and an abrupt interface with adjacent breast tissue. |
 Figure 5.1.8 The epithelium is evenly distributed in this fibroadenoma. |
 Figure 5.1.9 The bosselated edge and evenly distributed small glandular structures are characteristic of fibroadenoma. |
 Figure 5.1.4 Focally a residual duct wall lining is present in this sclerosed intraductal papilloma (upper right). |
 Figure 5.1.5 Sclerotic intraductal papilloma with entrapped glandular elements mimicking the pericanalicular pattern of a fibroadenoma. Note the previous biopsy site (lower left). |
 Figure 5.1.6 Entrapped glands in this sclerosed intraductal papilloma are distorted, but have a parallel arrangement and maintain a dual cell population. |
 Figure 5.1.10 Several small nodular proliferations demonstrate a pericanalicular growth pattern in this fibroadenoma. |
 Figure 5.1.11 Epithelium rings a nodular proliferation of stroma in this fibroadenoma. |
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 Figure 5.2.1 Clustered micropapillomas containing florid hyperplasia: Several lobular units and terminal ducts are expanded by an epithelial proliferation. |
 Figure 5.2.5 Nipple duct adenoma consists of a nodular proliferation of epithelium involving nipple ducts just beneath the skin. |
 Figure 5.2.2 A lobulocentric configuration is maintained despite distortion of these clustered micropapillomas by hyperplasia. |
 Figure 5.2.3 The fibrovascular cores of these clustered micropapillomas are almost obliterated by florid hyperplasia without atypia. |
 Figure 5.2.4 Uneven cell placement and nuclear variability are defining of florid hyperplasia involving a micropapilloma. Note the sclerosed fibrovascular cores (bottom). |
 Figure 5.2.6 The nipple ducts contain an exuberant epithelial proliferation with numerous slit-like spaces characteristic of florid hyperplasia without atypia. |
 Figure 5.2.7 The florid hyperplasia without atypia involving this nipple duct adenoma has slit-like peripheral secondary spaces and the cell placement is irregular. Focal punctate necrosis is common in this setting. |
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 Figure 5.3.1 Intraductal papilloma: The encysting fibrous duct wall surrounds arborizing fibrovascular cores, lined by proliferating epithelium; central sclerosis contains entrapped glands. |
 Figure 5.3.2 A sclerosed intraductal papilloma with maintenance of arborizing fibrovascular cores. Only a small portion of the duct lumen with lining remains (far right). |
 Figure 5.3.3 Small glandular structures are separated by intervening stroma. Focally the epithelium has apocrine cytology. |
 Figure 5.3.7 Adenomyoepithelioma with a characteristic lobulated and solid appearance at low magnification. |
 Figure 5.3.8 The epithelial proliferation in adenomyoepithelioma is predominantly solid, with an encysting fibrous rind, a remnant of a former duct wall. |
 Figure 5.3.9 The lobulations of this adenomyoepithelioma contain a solid, spindle cell proliferation centrally and glandular elements at the periphery. |
 Figure 5.3.4 Glandular structures contain luminal epithelial and myoepithelial cells. |
 Figure 5.3.5 The epithelium of the papilloma shows a mixture of epithelial and myoepithelial cells. |
 Figure 5.3.6 Myoepithelial cells are prominent in this intraductal papilloma, but foci of solid growth are absent. |
 Figure 5.3.10 Glandular elements are intermixed with the solid, spindled proliferation in this adenomyoepithelioma. |
 Figure 5.3.11 A solid proliferation of myoepithelial cells showing spindled but varied nuclei that are overlapping in this adenomyoepithelioma. |
 Figure 5.3.12 The proliferating myoepithelial cells have spindled nuclei and clear cytoplasm in this adenomyoepithelioma. Note adjacent glandular differentiation. |
 Figure 5.3.13 Adenomyoepithelioma showing an area of glandular differentiation. Nuclear variability and overlap are characteristic. |
 Figure 5.3.14 Immunohistochemical expression of nuclear p63 by the myoepithelial component of an adenomyoepithelioma |
 Figure 5.3.15 Immunohistochemical expression of high molecular weight cytokeratin (CK5/6) by the spindled myoepithelial proliferation in adenomyoepithelioma. |
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