Panfolliculoma
Steven D. Billings, MD
Key Facts
Microscopic Pathology
Closely set solid and partially cystic structures with follicular differentiation
Well circumscribed
Follicular differentiation represents all areas of follicular unit
Cystic areas resembling infundibulum with stratified squamous epithelium with granular layer and basket-weave stratum corneum
Areas resembling internal and external root sheath
Areas with matrical epithelium
Areas resembling hair bulb
Top Differential Diagnoses
Trichoblastoma
Lacks more advanced follicular differentiation
Trichoepithelioma
Also lacks more advanced follicular differentiation
 Panfolliculoma is characterized by a dermal-based adnexal proliferation recapitulating all levels of the hair follicle. |
 Panfolliculoma shows cystic areas lined by stratified squamous epithelium with a granular layer  , basaloid epithelium with papillary mesenchymal bodies  , and inner and outer root sheath  . |
TERMINOLOGY
Definitions
Benign tumor with differentiation that represents all segments of the hair follicle
CLINICAL ISSUES
Epidemiology
Incidence
Very rare
Age
Adults
Gender
Men and women affected equally
Site
Usually involving face or scalp but may occur elsewhere
Presentation
Mass lesion
Slowly growing
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