or serum concentration by autoanalyzer photometry using a chromatogenic reagent such as xylidyl blue. The color produced, measured bichromatically at 520/800 nm, is proportional to the magnesium concentration (2).
Figure 7-1 Schematic display of normal overall body homeostasis of magnesium, including an approximate distribution in different tissues. GI, gastrointestinal; RBC, red blood cells. |
animals occurs primarily in the more distal portion of the small intestine, namely the jejunum and ileum (10). The small intestinal magnesium absorption appears to occur down an electrochemical gradient through a paracellular pathway.
Table 7-1 Magnesium Transporters | ||||||||||||||||||||||||||||||||||||||||||||||||||||
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Table 7-2 Genetic Causes of Hypomagnesemia | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Figure 7-2 Normal distribution of magnesium reabsorption as a percentage of the ultrafilterable magnesium at the glomerulus. |
1920 (32). Magnesium plays a critical and necessary role in intracellular metabolism. Magnesium is necessary for a wide spectrum of enzymatic reactions, including various phosphokinases and phosphatases (33), which are involved in energy storage and use. Phosphatases are particularly important because magnesium functions primarily to form magnesium ATP, which is a substrate for these enzymes. These ion-sensitive ATPases are situated in the intracellular compartments and membranes to regulate the flow of potential energy from the mitochondria and cytoplasm. Recognized magnesium ATPases include ouabain-sensitive Mg2+/Na+/K+ATPase, ouabain-insensitive Mg2+, HHCO3ATPase, and Mg2+/Ca2+ATPase, which are associated with the sodium, proton, and calcium pumps, respectively. They are all essential for ionic control of the cell composition (34). Magnesium also is involved in protein synthesis through its action on nucleic acid polymerization, its role in ribosomal binding to ribonucleic acid (RNA), and in the synthesis and degradation of deoxyribonucleic acid (DNA). In addition to its role in phosphorylation of glucose, magnesium may also control mitochondrial oxidative metabolism (35). Adenylate cyclase, critical in the generation of the intracellular secondary messenger 3′,5′-cyclic adenosine monophosphate (cAMP), also has been shown to be dependent on magnesium (36). Intracellular magnesium has also been shown to have an important regulatory function on both K+ and Ca2+ channels (37).
that the magnesium malabsorption might be a consequence of the formation of insoluble magnesium soaps. Supporting this possibility is the finding that magnesium absorption was improved when the patients were placed on a low-fat diet. The small bowel diseases with the highest incidence of hypomagnesemia are idiopathic steatorrhea and disease of the distal ileum.
Table 7-3 Causes of Hypomagnesemia | ||||||||||||||||||||||||||
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following jejunoileal bypass surgery for the treatment of morbid obesity, probably from a combination of factors, including malabsorption, shortened transit time, and diarrhea (46).