Nesidioblastosis



Nesidioblastosis


Vikram Deshpande, MD





Key Facts


Terminology



  • Morphologic findings associated with functional disorders of β cells (hyperinsulinemic hypoglycemia) in absence of insulinoma


Etiology/Pathogenesis



  • Abnormalities in potassium channels


Clinical Issues



  • Persistent neonatal hypoglycemia


  • Adult NB very rare


Microscopic Pathology



  • Neonatal focal NB



    • Confluent or partially confluent clusters of endocrine cells


  • Neonatal diffuse NB



    • Giant endocrine cells (3x larger than normal endocrine cells)






This image shows predominantly unremarkable pancreatic acinar tissue. Large and back to back islet celllike structures image are present, a finding that suggests focal nesidioblastosis.






Focal nesidioblastosis features confluent growth of endocrine cells image. The endocrine cells are very similar to those seen in normal pancreatic islets. Note the intervening normal acinar cells image.


TERMINOLOGY


Abbreviations



  • Nesidioblastosis (NB)


Definitions



  • Morphologic findings associated with functional disorders of β cells (hyperinsulinemic hypoglycemia) in absence of insulinoma


ETIOLOGY/PATHOGENESIS


Potassium Channel Abnormalities

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Jul 7, 2016 | Posted by in PATHOLOGY & LABORATORY MEDICINE | Comments Off on Nesidioblastosis

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