Objectives
- List the features distinguishing nerve tissue from other basic tissue types.
- List the nerve tissue cell types and describe the structure, function, location, and embryonic origin of each.
- Describe in detail how neurons receive, propagate, and transmit signals.
- Describe a neuron’s organelles in terms of their location and roles in impulse transmission and neuronal repair.
- Describe synapses in terms of their structural components, function, and classification.
- Describe nervous system organization in terms of the structure, functions, location, and distinguishing features of its subsystems.
- Describe the structure and function of the meninges.
- Describe the response of nerve tissue to injury.
- Recognize the type of nerve tissue displayed in a micrograph and identify its cells and cell processes.
MAX-Yield™ Study Questions
2. Compare the central nervous system (CNS) and peripheral nervous system (PNS) (I.D.1; Table 9–1) in terms of:
Major components (organs)
Names given to a collection of nerve cell bodies
Names given to a collection of nerve cell fibers
Supporting cells present
Cells responsible for myelination
Cells that invest unmyelinated fibers
Embryonic origin
Predominant neuronal components (cell bodies, axons, dendrites)
Amount of myelin present
Predominant astrocyte type (III.A.1)
Abundance of synapses
5. Compare the sympathetic and parasympathetic nervous systems (I.D.2; Fig. 9–1; Table 9–2) in terms of the locations of cell bodies of preganglionic and postganglionic neurons, the neurotransmitter released by their postganglionic neurons, and their primary function (sensory or motor).
6. Beginning with neural plate formation, list the basic steps in nervous system development (I.E; Fig. 9-2).
9. Describe the blood–brain barrier in terms of its structural correlates and its function (I.H;III.A.1).
10. Compare multipolar, bipolar, and pseudounipolar neurons (II. D; Table 9–3) in terms of their number of axons and dendrites, typical function, and location in the body (include examples).
Number per neuron
Relative length
Presence of surface projections
Primary function
Presence of Nissl bodies (RER and ribosomes)
Degree of branching
Variation in diameter as a function of distance from the perikaryon
Content of synaptic vesicles
12. Draw a terminal bouton and its associated synapse (see Fig. 9–3) and label the synaptic vesicles, mitochondria, presynaptic membrane, synaptic cleft, and postsynaptic membrane.
13. Compare protoplasmic astrocytes and fibrous astrocytes in terms of their location and the length and diameter of their cell processes (III.A.1).
Nuclear shape, size, and staining intensity
Relative number of cell processes
Ability to form myelin
Relationship to the mononuclear phagocyte system
Cytoplasmic staining properties and visibility (II.A; III.A)
Nuclear size (III.A)
Relative number in the CNS (III.A)
Capacity for proliferation in adults (VIII.A and B.1)
Embryonic origin (I.E)
General function (I.A.1 and 2)
17. Which part of a Schwann cell forms the myelin sheath, and what is the predominant biochemical constituent of myelin (III.B.1)?
Impulse conduction velocity (I.B)
Diameter (Table 9–5)
Presence of nodes of Ranvier (III.B.1)
Action potential (diffusion versus saltatory conduction) (VII.B.2 and 5)
Location
Number of axons each can myelinate
Number of cells per internode
Whether they ensheathe unmyelinated axons
Location
Primary function (motor or sensory)
Class of neurons present
Distribution of ganglion cell bodies
Nuclear shape and position in ganglion cell bodies
Completeness of satellite cell layer
21. How do the ganglion cells of the spiral (acoustic) ganglion differ from those in craniospinal ganglia (Table 9–4)?
23. Draw a peripheral nerve cross-section (VI; Fig. 9–4) and label the epineurium, perineurium, endoneurium, myelin sheaths, and axons.
24. Compare the inside and outside of a resting-state neuron in terms of K+ and Na+ ion concentrations and approximate resting membrane potential in millivolts (VII.B.1).
26. Beginning with an excitatory synaptic stimulus, list the events leading to the generation of an action potential (VII.B.2).
27. After depolarization, how does a neuron reestablish its resting membrane potential (VII.B.2 and 3)? Does this process require ATP? How long does it take?
28. Beginning with the spread of an action potential into a terminal bouton, list the sequence of events leading to depolarization of a postsynaptic membrane (IV.A–C).
31. Compare nerve fibers (types A, B, and C) in terms of myelination, fiber diameter, and internode length (Table 9–5).
Distal stumps of injured axons
Myelin distal to the cut
Schwann cells distal to the cut
Nissl bodies of perikarya
Volume of perikarya
Position of nuclei in perikarya
Proximal stumps of injured axons
Synopsis
Nerve tissue consists of neurons that transmit electrochemical impulses and the supporting cells that surround them. It contains little extracellular material.
Neurons (II). These cells are specialized to receive, integrate, and transmit electrochemical messages. Each has a cell body, also called the soma (“body”) or perikaryon (“around the nucleus”), comprising the nucleus, the surrounding cytoplasm, and the plasma membrane. Each neuron has a variable number of dendrites (cytoplasmic processes that collect incoming messages and carry them toward the soma) and a single axon (a cytoplasmic process that transmits messages to the target cell). Axons of most neurons have a myelin sheath formed by supporting cells and interrupted by gaps called nodes of Ranvier. Axon segments between the gaps are called internodes.
Supporting cells (III) are called neuroglia (“nerve glue”) or glial cells. Their functions include structural and nutritional support of neurons, electrical insulation, and enhancement of impulse conduction velocity (VII.B.2 and 5).
Signals (impulses) are propagated as a wave of depolarization along the plasma membrane of the dendrites, soma, and axon. Depolarization involves channels (ionophores) in the membrane, which allow ions (e.g., Na+, K+) to enter or exit the cell. In unmyelinated axons, depolarization occurs in waves over the entire surface. In myelinated axons, depolarization occurs only at nodes of Ranvier, jumping from node to node (saltatory conduction). Impulse conduction is therefore faster in myelinated axons.
Signals pass from neuron to target cell by specialized junctions called synapses. A target may be another neuron or a cell in the end-organ (e.g., gland or muscle). At chemical synapses (IV), signals are transmitted by the exocytosis of neurotransmitters—chemicals such as acetylcholine that cross a narrow gap (synaptic cleft) between cells to initiate target cell depolarization. At the less common electrical synapses, signals are transmitted by ions flowing through a gap-junction–like complex.