Nephrogenic Fibrosing Dermopathy (Nephrogenic Systemic Fibrosis)

Nephrogenic Fibrosing Dermopathy (Nephrogenic Systemic Fibrosis)

Cary Chisholm, MD

This patient is unable to open her hand due to indurated skin. She had been given gadolinium contrast months before. The skin is firm but not bound down as in scleroderma.

There is an increased population of spindle-cell histiocytes and fibroblasts with gray/blue mucin deposition image.



  • Nephrogenic fibrosing dermopathy (NFD)


  • Nephrogenic systemic fibrosis (NSF)


  • Scleromyxedema-like dermatosis that affects only patients with renal failure


Environmental Exposure

  • Gadolinium administration prior to magnetic resonance (MR) imaging

    • Gadodiamide (Omniscan) and gadopentetate (Magnevist) specifically

      • Have been given to virtually every reported patient prior to disease manifestation

      • Have been identified within lesional tissue

      • Stored in bone and slowly released over time

Jul 8, 2016 | Posted by in PATHOLOGY & LABORATORY MEDICINE | Comments Off on Nephrogenic Fibrosing Dermopathy (Nephrogenic Systemic Fibrosis)

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