Male Genitalia

Male Genitalia

… The husband had long been suffering from ulcers in the private parts, and his wife insisted on seeing them, promising that no one would give him a more candid opinion whether the disease was curable. She saw that there was no hope and urged him to take his life; she went with him, even led him to his death herself, and forced him to follow her example by roping herself to him and jumping into the lake.


Embarrassment and anxiety on the part of both patient and physician can cause harmful or even fatal delays in the recognition and treatment of diseases in the genital region. Physicians do a great disservice to patients by neglecting this aspect of the physical examination. As with the female genital exam, the physician must take care to respect the modesty of the patient.


A Method

  • Put on a pair of gloves, remembering that some organisms such as Treponema pallidum can be infective through the skin1 (Harrison et al., 1978).

  • Inspect the penis, looking for any ulcerative or exophytic lesions. Remember to retract the foreskin, if present, or have the patient do so. (Be sure to return the foreskin to its usual state; unconscious patients have developed severe edema after the examiner failed to do this.) Do not retract the foreskin if it is painful or too tight (see phimosis, discussed later in this chapter).

  • In order to inspect for ulcers, warts, and discharge, open the terminal urethra by compressing the glans anteroposteriorly between your thumb and forefinger. Note the location of the urethral meatus, normally at the tip of the glans penis.

  • To detect masses, induration, or tenderness, palpate the length of the shaft, including the lateral corpora cavernosa as well as the length of urethra.


The distinguishing features of ulcers of various etiologies are given in Table 21-1 (Figs. 21-1, 21-2 and 21-3). Additionally, fixed drug eruptions can affect the genitalia, causing intensely painful bullous lesions that may become necrotic. Some patients so afflicted have been mislabeled as having herpes simplex. As always, a complete drug history is warranted (Goldman, 2000).

The mucous membrane of the urethra may be involved in systemic diseases that cause mucosal ulcerations, such as Behçet disease, pemphigus, and Stevens-Johnson syndrome.

Other Skin Lesions

Nonulcerating dermatologic diseases that characteristically involve the penis include psoriasis, scabies, and lichen planus.

Psoriasis is the most common inflammatory condition affecting the male genitalia. The patient may have no history of psoriasis or lesions elsewhere and the well-defined erythematous plaques lack the characteristic psoriatic scale (Goldman, 2000).

Contact dermatitis may result from topical agents applied to other areas and transferred to the genitalia from the hands. Obtain a complete history of the use of such preparations. Poison ivy and other forms of Rhus dermatitis are also transferred in this way.

In secondary lues, a papulosquamous eruption typically involves the penis, palms (Fig. 21-4), and soles. This skin lesion is teeming with spirochetes and is highly infectious.

Reiter syndrome is frequently accompanied by circinate balanitis, a painless eruption on the glans. These begin as small blebs that coalesce into a large circular ring about the size of a dime.

Condylomata lata (See Fig. 22-5) are flat growths about the genitalia or anus seen during the secondary stage of syphilis. Condylomata acuminata (venereal warts), which occur in the same locations (See Fig. 22-4), have villous projections, and as these are caused by a virus, they are infectious.

Herpes simplex can initially appear as small grouped vesicles on an erythematous base, which then open and resolve as ulcers. These are highly infectious.

Malignant melanomas occur on the male genitalia, most commonly on the glans or urethra, but are very rare, much rarer than on the vulva (Ahmed, 1997).

TABLE 21.1 Ulcers of the penis


Usual number




One (but multiple chancres not rare)

No (unless superinfected)

Usually bilateral




Bilateral but usually more pronounced on one side

Granuloma inguinale

One (more likely to be inguinal)



Lymphogranuloma venereum

One (tiny, vesicular)

Not usually but the lymphadenopathy is painful

Usually unilateral

Herpes simplex

Multiple (vesicular at first), occur in clusters





Not initially


FIGURE 21-1 Primary syphilis. A: Meatal chancre. B: Primary chancres of the penile shaft, showing that these can be multiple. The lesions are usually firm and indurated with a crusted or ulcerated surface and a raised border. The size varies from a few millimeters to 1 or 2 cm. (Courtesy of Division of Sexually Transmitted Diseases, Center for Prevention Services, Centers for Disease Control, Atlanta, GA.)

FIGURE 21-2 Chancroidal ulcers. Lesions are generally multiple, soft, ulcerated with a grayish base, and quite tender. Dark-field examination is negative: Haemophilus ducreyi may be demonstrated from the lesion by direct smear or culture. (Courtesy of Division of Sexually Transmitted Diseases, Center for Prevention Services, Centers for Disease Control, Atlanta, GA.)

FIGURE 21-3 Granuloma inguinale, with both active and healed areas. (Courtesy of Division of Sexually Transmitted Diseases, Center for Prevention Services, Centers for Disease Control, Atlanta, GA.)

FIGURE 21-4 The papulosquamous eruption of secondary syphilis. (Courtesy of Division of Sexually Transmitted Diseases, Center for Prevention Services, Centers for Disease Control, Atlanta, GA.)

Cancer of the penis can be either nodular or ulcerating. While it is rare, morbidity and mortality are relatively high because of delays in diagnosis occasioned by embarrassment, denial, or lack of awareness.


Record whether the patient is circumcised. If not, be sure to retract the foreskin completely and inspect the complete coronal sulcus and glans.

In the event that urine cultures for mycobacteria are done to look for extrapulmonary dissemination of tuberculosis, be aware that laboratories unable to distinguish species could mistake Mycobacterium smegmatis, a contaminant present in the smegma of uncircumcised men, for Mycobacterium tuberculosis.

Penile cancer hardly ever occurs in circumcised men. (Cancer of the cervix is also less common in the wives of circumcised men.)


Phimosis is the inability to retract the foreskin because of a congenital malformation, adhesions from infection, or scarring from traumatic retraction of the foreskin during childhood or adulthood.


Paraphimosis is the inability to replace the foreskin because of phimotic cicatrix that squeezes down on the penis behind the coronal sulcus. This causes severe pain and edema of the glans because of obstruction of lymphatic and venous return. It can easily be misdiagnosed as glanular edema if the examiner does not realize that the patient is not circumcised. The foreskin needs to be replaced immediately; this usually requires urologic consultation.

Peyronie Disease

Peyronie disease is also known as plastic induration of the penis. The patient may complain of curvature of the penis during erection, toward the side of the plaque. Feel for plaques, which are occasionally tender, in the corpora cavernosa laterally or in the intercorporeal septum dorsally. The condition is more common in men who have used penile self-injections to treat impotence.


Priapism is a prolonged, usually painful erection of the corpora cavernosa, initially unaccompanied by sexual desire. The glans penis is usually not engorged. It may signify a neurologic lesion from the cerebrum to the nervi erigentes; a local mechanical cause, such as thrombosis, hemorrhage, neoplasm, or inflammation of the penis; or a thrombotic diathesis due to a hematologic condition such as leukemia or sickle cell anemia (hemoglobin S-S), or even sickle trait (hemoglobin S-A). (Hemoglobin S undergoes sickling when the partial pressure of oxygen in the blood decreases [PO2]. Persons with hemoglobin S-A usually have PO2 levels sufficient to prevent sickling—except when they travel by air.) Additional causes of priapism include Fabry disease, amyloidosis, malaria, black widow spider bite, and recent infection with Mycoplasma pneumoniae.

Priapism can also be seen following self-injection of vasoactive agents, as well as use of some oral agents. Up to 21% of cases of priapism are associated with alcohol abuse or drug therapy (Thomas et al., 2003). Take a careful drug history, including the use of illegal agents. Drugs associated with this condition include many psychotropic medications (including chlorpromazine, clozapine, bupropion, trazodone, fluoxetine, sertraline, lithium, mesoridazine, perphenazine, and hydroxyzine), hydralazine, metoclopramide, prazosin, tamoxifen, testosterone, calcium-channel blockers, anticoagulants, cocaine, marijuana, and 3,4-methylenedioxymethamphetamine (MDMA or “ecstasy”). Priapism has also been reported with infusion of a 20% fat emulsion in the course of total parenteral nutrition.

image Most men have delayed presentation for many hours because of embarrassment. Delay increases the likelihood of complications such as impotence. Priapism is an emergency requiring immediate treatment.

Congenital Malformations

In hypospadias, the urethra opens on the ventral surface of the penis, from just inside the meatus all the way down the shaft to the penoscrotal junction. This may occur as an isolated anomaly (in 1 of 700 newborn boys). In about 15% of cases, there is some pathogenetic mechanism identified, such as in Klinefelter syndrome (karyotype XXY), other chromosomal abnormalities, maternal ingestion of estrogens or progestogens, or virilizing congenital adrenal hyperplasia in a genetic female (Williams, 1974). Hypospadias may accompany nondescent of the testicle. An asymmetric “hooded” foreskin is often seen with hypospadias.

In epispadias, the urethra opens dorsally.

Urethral Discharge and Urethritis

A thick, purulent-appearing discharge is likely to be a sign of gonorrhea. A slight, whitish discharge is more likely to be due to one of the causes of “nonspecific” (nongonococcal) urethritis
such as Chlamydia, Ureaplasma, or even a presumably noninfectious condition such as Reiter syndrome. Place a drop of the discharge on a slide, allow it to air dry, and prepare a Gram stain to look for leukocytes and gonococci (see Chapter 28).

Sexually transmitted diseases (STDs) may be present even in the absence of symptoms and may only come to the patient’s attention because of a diagnosis made in a partner (see Chapter 22). Men attending an STD clinic were found to have a 17% prevalence of Trichomonas, 19.6% of chlamydia, and 17.7% of gonorrhea. In men with nongonococcal urethritis, 19% were infected with Trichomonas (Schwebke and Hook, 2003).

Impotence (Erectile Dysfunction)

The physical examination of the penis is seldom helpful in evaluating one of the major causes of morbidity in men, sexual impotence (erectile dysfunction [ED]), unless it is a result of an end-organ problem such as Peyronie disease, phimosis, microphallus, or chordee (Nelson, 1987).

One special maneuver, the postage-stamp test (see Chapter 3), is useful for distinguishing impotence of a central (psychogenic) origin from that secondary to a problem in the neurovascular axis (endocrine, vascular, peripheral neuropathy, etc.). Vascular impotence may be evaluated by measuring the penile-brachial blood pressure gradient (see Chapter 18) but requires Doppler equipment to make the penile artery pressure determination.

See Chapter 3 for a discussion of the history and differential diagnosis in ED.

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Aug 10, 2020 | Posted by in GENERAL & FAMILY MEDICINE | Comments Off on Male Genitalia

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