Lobomycosis



Lobomycosis


Patricia J. Alvarez, MD

Francisco G. Bravo, MD










Lobomycosis clinically shows confluent keloidal lesions on the anterior region of the outer ear, which is a frequent location.






Lobomycosis shows an atrophic epidermis with a grenz zone image. The dermis shows fibrosis and a diffuse infiltrate of macrophages and multinucleated giant cells image.


TERMINOLOGY


Synonyms



  • Keloidal blastomycosis, Jorge Lobo disease, lacaziosis


Definitions



  • Chronic, granulomatous fungal disease caused by Lacazia loboi that affects skin and subcutaneous tissue


ETIOLOGY/PATHOGENESIS


Infectious Agents



  • Lacazia loboi is an intracellular agent known to cause disease in humans, salt water and fresh water dolphins


  • Soil and vegetation are likely sources of infection


  • L. loboi accesses skin by penetration or accidental trauma such as thorn prick or insect bite


  • Once in dermis, fungus is phagocytized, initiating slow-growing process of multiplication


  • Some suggest lymphatic dissemination, although hematogenous and contiguity are also hypotheses

Jul 8, 2016 | Posted by in PATHOLOGY & LABORATORY MEDICINE | Comments Off on Lobomycosis
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