Carefully note the site of the biopsy, using a standard nomenclature for liver segments (see Chapter 82 for a thorough discussion of liver segments). At a minimum, document which lobe (right or left) and whether the abnormality is isolated, one of many similar nodules, or generalized. Clearly, if there is a focal abnormality, the biopsy should include part or all of that abnormality. For a generalized process, such as hepatic cirrhosis, liver biopsy is most easily performed at the free edge of the left or right lobe. If any obvious abnormalities are present, however, obtain the biopsy specimen from the affected area. If there are no visible or palpable masses, the free edge of the right lobe, away from any areas that may have been damaged in the course of dissection or by placement of retractors, should be selected. This area is selected because it is generally representative and easy to approach. It is relatively to get hemostasis with sutures if persistent bleeding is encountered.