Lipodermatosclerosis



Lipodermatosclerosis


Wang L. Cheung, MD, PhD










End-stage lipodermatosclerosis in this patient shows “inverted wine bottle” deformity and distal, shrunken, indurated lower extremities.






Low-power view of LDS demonstrates distinct eosinophilic material image (feathery or arabesque pattern) in fatty cystic degeneration.


TERMINOLOGY


Abbreviations



  • Lipodermatosclerosis (LDS)


Synonyms



  • Sclerosing panniculitis, membranous lipodystrophy, sclerodermiform hypodermitis


Definitions



  • Venous insufficiency leading to skin induration and ulceration


ETIOLOGY/PATHOGENESIS


Probably Venous Disease Leading to Skin Ulceration



  • Some association with obesity, hypercoagulable state (protein C and S deficiencies)


  • Some association with connective tissue disease


  • Excessive matrix metalloproteinases (MMP) activity

Jul 8, 2016 | Posted by in PATHOLOGY & LABORATORY MEDICINE | Comments Off on Lipodermatosclerosis
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