Depending on the habitus of the patient, the nature of the pathology, and the mobility of the small bowel, there are several approaches that can be used in laparoscopic small bowel resection and anastomosis. The technique shown here uses laparoscopic mobilization and mesenteric division, followed by extracorporeal completion of resection and anastomosis. It is also possible to construct a fully intracorporeal anastomosis. The advantages are minor, however, because an incision must be made to retrieve the specimen. In some circumstances, the entire mesenteric division and anastomosis may be done after exteriorizing the specimen—the laparoscope then is used simply to localize and elevate the relevant loop. References at the end of this chapter give further technical tips on applications in the setting of adhesive small bowel obstruction and small bowel tumors.